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PMID: 4673577 Published · ppublish English Journal Article

Deficiency of alpha-mannosidase in Angus cattle. An inherited lysosomal storage disease.

The Biochemical journal ·Vol. 128 ·No. 1 ·1972-06-00 ·Pages 69-78

Hocking JD, Jolly RD, Batt RD

Abstract

A disease of Angus cattle previously known as pseudolipidosis has been shown to be an inherited lysosomal storage disease, in which an oligosaccharide containing mannose and glucosamine is the storage substance. Diseased animals have a near-absolute deficiency of the lysosomal enzyme, alpha-mannosidase, whereas heterozygotes have a partial deficiency of this enzyme. The condition is analogous to the human disease known as mannosidosis.

MeSH Terms
Animals Brain/enzymology Cattle Cattle Diseases/enzymology Chick Embryo Chromatography, Paper Female Glucosamine Hexosaminidases Hexoses Lipid Metabolism, Inborn Errors/veterinary Liver/enzymology Lymph Nodes/enzymology Lysosomes/metabolism Male Mannose
Chemicals
Hexoses Hexosaminidases Glucosamine Mannose
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hocking J D
Jolly R D
Batt R D
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23 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1280069
Published
1972-06-00
Pages
69-78
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1173571
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1280069 PMC Full Text View journal details
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