Effects of clozapine on cerebral catecholaminergic neurone systems.

British journal of pharmacology ·Vol. 46 ·No. 4 ·1972-12-00 ·Pages 736-40

Bartholini G, Haefely W, Jalfre M, Keller HH, Pletscher A

Abstract

1. Clozapine, a dibenzodiazepine derivative claimed to possess antipsychotic properties in man without producing extrapyramidal disorders, greatly increased the turnover of cerebral dopamine in the rat.2. The drug itself was virtually devoid of cataleptigenic activity in rats; however, it antagonized prochlorperazine-induced catalepsy.3. It is proposed that clozapine causes a blockade of striatal dopamine receptors which is of the surmountable type in contrast to that produced by cataleptigenic neuroleptics. In addition, clozapine may also increase the turnover of cerebral noradrenaline.

MeSH Terms

Animals Brain/drug effects Brain Chemistry/drug effects Catalepsy/chemically induced Catecholamines/metabolism Dibenzazepines/pharmacology Dopamine/analysis,metabolism Humans Hypothermia/chemically induced Male Norepinephrine/analysis Phenylacetates/analysis Piperazines/pharmacology Prochlorperazine/antagonists & inhibitors Rats Tranquilizing Agents/pharmacology

Chemicals

Catecholamines Dibenzazepines Phenylacetates Piperazines Tranquilizing Agents Dopamine Norepinephrine Prochlorperazine

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Bartholini G

Haefely W

Jalfre M

Keller H H

Pletscher A

References (6)

6 references, click to expand

The fluorometric assay of catecholamines and related compounds: improvements and extensions to the hydroxyindole technique.
Anal Biochem. 1968 Feb;22(2):269-79 PMID: 4868086
Effect of drugs used in psychoses on cerebral dopamine metabolism.
Br J Pharmacol. 1970 Feb;38(2):287-304 PMID: 4984801
The effect of tropolone on the formation of 3,4-dihydroxyphenylacetic acid and 4-hydroxy-3-methoxyphenylacetic acid in the brain of the mouse.
Br J Pharmacol. 1969 May;36(1):107-15 PMID: 5768081
Sinistrotorsion in guinea pigs as a method of screening central anticholinergic activity.
Arch Int Pharmacodyn Ther. 1962 Jun 1;137:375-82 PMID: 14452364
The pharmacology of 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine (clozapine).
Farmaco Prat. 1971 Oct;26(10):603-25 PMID: 5157543
EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN.
Acta Pharmacol Toxicol (Copenh). 1963;20:140-4 PMID: 14060771

Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1972.tb06898.x

Published

1972-12-00

Pages

736-40

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1666362

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1972.tb06898.x PMC Full Text View journal details

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Effects of clozapine on cerebral catecholaminergic neurone systems.

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