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PMID: 4682835 Published · ppublish English Journal Article

A fine structural characterization of the proliferated endocrine cells in atrophic gastric mucosa.

The American journal of pathology ·Vol. 70 ·No. 1 ·1973-01-00 ·Pages 109-18

Rubin W

Abstract

This study shows that most of the proliferated endocrine cells in nonintestinalized epithelium in the body of stomachs in patients with pernicious anemia have the fine structure of ECL (enterochromaffin-like) cells, the principal endocrine cell in the body of normal stomachs, and notes an absence of G (gastrin) cells, the principal endocrine cell in the normal pylorus. Since gastrin has been identified in many of these proliferated cells by immunofluorescence, these findings question the position that gastrin synthesis in the stomach is only associated with G cells.

MeSH Terms
Anemia, Pernicious/pathology Epithelial Cells Gastric Mucosa/pathology Gastrins/biosynthesis Humans Intestinal Mucosa/metabolism Microscopy, Electron
Chemicals
Gastrins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Rubin W
References (31)
31 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1973-01-00
Pages
109-18
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1903915
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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