Home LiteratureArticle Details
PMID: 4687914 Published · ppublish English Journal Article

A morphometric study on the nexus of rat cardiac muscle.

The Journal of cell biology ·Vol. 56 ·No. 3 ·1973-03-00 ·Pages 690-6

Matter A

Abstract

A morphometric study of the nexus of rat cardiac muscle was carried out. The nexus surface of one intercalated disk of one 15 microm thick fiber is found to range between 47 microm(2) and 94 microm(2), the latter value taking into account the maximal underestimation caused by tangential sectioning. Dividing the lower, minimal value by the surface of the observed subunits (90 A periodicity), one obtains for one intercalated disk 6.7 x 10(5) subunits, each of them assumed to be permeated by a central pore. These pores are thought to be equivalent to intercellular channels in a recently proposed model. Taking our morphometric and recently reported physiological values, this model is examined for its consistency with a low resistance pathway between cardiac muscle cells.

MeSH Terms
Animals Biometry Desmosomes Male Microscopy, Electron Mitochondria, Muscle Muscles/cytology Myocardium/cytology Myofibrils Rats
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Matter A
References (25)
25 references, click to expand
  1. An interpretation of liver cell membrane and junction structure based on observation of freeze-fracture replicas of both sides of the fracture.
    J Cell Biol. 1970 Oct;47(1):49-60 PMID: 4935338
  2. Hexagonal array of subunits in intercellular junctions of the mouse heart and liver.
    J Cell Biol. 1967 Jun;33(3):C7-C12 PMID: 6036535
  3. Improvements in epoxy resin embedding methods.
    J Biophys Biochem Cytol. 1961 Feb;9:409-14 PMID: 13764136
  4. THE OCCURRENCE OF A SUBUNIT PATTERN IN THE UNIT MEMBRANES OF CLUB ENDINGS IN MAUTHNER CELL SYNAPSES IN GOLDFISH BRAINS.
    J Cell Biol. 1963 Oct;19:201-21 PMID: 14069795
  5. Homo- and heterocellular junctions in cell cultures: an electrophysiological and morphological study.
    Prog Brain Res. 1969;31:283-311 PMID: 4899410
  6. Electrotonic junctions between teleost spinal neurons: electrophysiology and ultrastructure.
    Science. 1963 Jul 19;141(3577):262-4 PMID: 13967485
  7. Electrical constants of trabecular muscle from mammalian heart.
    J Physiol. 1970 Nov;210(4):1041-54 PMID: 5501485
  8. Practical stereological methods for morphometric cytology.
    J Cell Biol. 1966 Jul;30(1):23-38 PMID: 5338131
  9. Electrical transmission at the nexus between smooth muscle cells.
    J Gen Physiol. 1968 Mar;51(3):347-68 PMID: 5648832
  10. Morphological correlates of increased coupling resistance at an electrotonic synapse.
    J Cell Biol. 1971 Apr;49(1):173-88 PMID: 4995387
  11. The nexus in the intercalated disc of the canine heart: quantitative data for an estimation of its resistance.
    J Ultrastruct Res. 1971 Mar;34(5):409-25 PMID: 5555016
  12. Cat heart muscle in vitro. I. Cell volumes and intracellular concentrations in papillary muscle.
    J Gen Physiol. 1960 Nov;44:327-44 PMID: 13732016
  13. Gap junctions in normal and transformed fibroblasts in culture.
    Exp Cell Res. 1972;71(2):393-401 PMID: 4339896
  14. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.
    J Cell Biol. 1963 Apr;17:208-12 PMID: 13986422
  15. Gap junctions between electrotonically coupled cells in tissue culture and in brown fat.
    Proc Natl Acad Sci U S A. 1971 Dec;68(12):2924-7 PMID: 5289236
  16. Electrical coupling between embryonic cells by way of extracellular space and specialized junctions.
    J Cell Biol. 1970 Mar;44(3):592-610 PMID: 5415239
  17. The ultrastructure of the nexus. A correlated thin-section and freeze-cleave study.
    J Cell Biol. 1970 Dec;47(3):666-88 PMID: 5531667
  18. Electrical coupling between fat cells in newt fat body and mouse brown fat.
    J Cell Biol. 1971 Sep;50(3):795-803 PMID: 4938627
  19. Electrical characteristics of tunicate heart cell membranes and nexuses.
    J Gen Physiol. 1968 Jul;52(1):46-59 PMID: 4913702
  20. A fine structural analysis of intercellular junctions in the mouse liver.
    J Cell Biol. 1970 May;45(2):272-90 PMID: 4105112
  21. Permanganate; a new fixative for electron microscopy.
    J Biophys Biochem Cytol. 1956 Nov 25;2(6):799-802 PMID: 13398447
  22. PROPAGATION OF ACTION POTENTIALS AND THE STRUCTURE OF THE NEXUS IN CARDIAC MUSCLE.
    J Gen Physiol. 1965 May;48:797-823 PMID: 14324989
  23. Junctions between intimately apposed cell membranes in the vertebrate brain.
    J Cell Biol. 1969 Mar;40(3):648-77 PMID: 5765759
  24. Intercellular Connection between Smooth Muscle Cells: the Nexus.
    Science. 1962 Aug 31;137(3531):670-2 PMID: 17770946
  25. Permeability and structure of junctional membranes at an electrotonic synapse.
    Science. 1969 Dec 26;166(3913):1641-3 PMID: 5360587
Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.56.3.690
Published
1973-03-00
Pages
690-6
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2108931
Subset
IM
External Links
PubMed source DOI: 10.1083/jcb.56.3.690 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2