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PMID: 46890 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Genetic control of the immune response to the H-2 associated Slp alloantigen in the mouse.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 114 ·No. 4 ·1975-04-00 ·Pages 1139-42

Passmore HC, Hansen TH

Abstract

A survey of sixteen standard inbred and congenic resistant strains of mice reveals that the ability to mount an immune response to the Slp allotype is associated with the H-2 type of the recipient. Strains carrying the H-2f, H-2k, and H-2q haplotypes are able to produce specific antibody whereas strains of the H-2b haplotype are non-responders. Analysis of F1-hybrids and four informative intra-H-2-recombinants demonstrates that the ability to respond to the Slp allotype is controlled by a dominant gene associated with the K end of the H-2 complex.

MeSH Terms

Animals Antibody Formation Chromosome Mapping Crosses, Genetic Crossing Over, Genetic Epitopes Female Genes, Dominant Histocompatibility Antigens Immune Sera Immunization Schedule Immunodiffusion Immunogenetics Male Mice Mice, Inbred C3H Mice, Inbred DBA Phenotype Recombination, Genetic Terminology as Topic

Chemicals

Epitopes Histocompatibility Antigens Immune Sera

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Passmore H C

Hansen T H

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1975-04-00

Pages

1139-42

Language

English

Region

United States

NLM ID

2985117R

Subset

External Links

PubMed source View journal details

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Genetic control of the immune response to the H-2 associated Slp alloantigen in the mouse.

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