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PMID: 4693151 Published · ppublish English Journal Article

Glucocorticoid suppression of macrophage migration inhibitory factor.

The Journal of experimental medicine ·Vol. 137 ·No. 4 ·1973-04-01 ·Pages 1031-41

Balow JE, Rosenthal AS

Abstract

The ability of hydrocortisone to modify antigen-mediated inhibition of macrophage migration, an in vitro correlate of cellular immunity in the guinea pig, was investigated. Only the glucocorticoids, hydrocortisone and dexamethasone, significantly blocked migration inhibitory factor (MIF) activity in pharmacologic concentrations. Hydrocortisone had no effect on antigen "processing" by macrophages, nor on the ability of antigen-stimulated peritoneal exudate lymphocytes to produce MIF. Rather, hydrocortisone antagonized directly the inhibitory effect of MIF on the macrophage.

MeSH Terms
Ascitic Fluid/immunology Cell Migration Inhibition Desoxycorticosterone/pharmacology Dexamethasone/pharmacology Dialysis Estrogens/pharmacology Glucocorticoids/pharmacology Hydrocortisone/pharmacology Immunization Lymphocytes/immunology Macrophages/immunology Progesterone/pharmacology Testosterone/pharmacology Tuberculin Test
Chemicals
Estrogens Glucocorticoids Testosterone Desoxycorticosterone Progesterone Dexamethasone Hydrocortisone
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Balow J E
Rosenthal A S
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32 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.137.4.1031
Published
1973-04-01
Pages
1031-41
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2139222
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.137.4.1031 PMC Full Text View journal details
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