Pyruvate metabolism by homogenates of human brain: effects of phenylpyruvate and implications for the etiology of the mental retardation in phenylketonuria.

Bicarbonates/metabolism Brain/cytology,drug effects,enzymology,metabolism Carbon Isotopes Decarboxylation Humans In Vitro Techniques Intellectual Disability/etiology Ketone Oxidoreductases/metabolism Ligases/metabolism Mitochondria/metabolism Phenylalanine/pharmacology Phenylketonurias/complications Phenylpyruvic Acids/pharmacology Pyruvates/antagonists & inhibitors,metabolism

Bicarbonates Carbon Isotopes Phenylpyruvic Acids Pyruvates Phenylalanine Ketone Oxidoreductases Ligases