Acetoacetate and brain lipogenesis: developmental pattern of acetoacetyl-coenzyme A synthetase in the soluble fraction of rat brain.

The Biochemical journal ·Vol. 132 ·No. 3 ·1973-03-00 ·Pages 653-6

Buckley BM, Williamson DH

Abstract

The existence of acetoacetyl-CoA synthetase in rat brain cytosol is reported. The coupling of this enzyme with cytosolic acetoacetyl-CoA thiolase can provide acetyl-CoA for lipogenesis and cholesterol synthesis without the need for mitochondrial participation. This new route for acetoacetate utilization may be important in developing brain.

MeSH Terms

Acetoacetates/metabolism Aging Animals Brain/cytology,enzymology,growth & development Coenzyme A Ligases/metabolism Cytosol/enzymology Female Fetus Lipids/biosynthesis Male Models, Biological Pregnancy Rats

Chemicals

Acetoacetates Lipids Coenzyme A Ligases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Buckley B M

Williamson D H

References (14)

14 references, click to expand

Changes in D(--)-beta-hydroxybutyric dehydrogenase activity during brain maturation in the rat.
J Biol Chem. 1967 Sep 10;242(17):3880-3 PMID: 4382562
Brain metabolism during fasting.
J Clin Invest. 1967 Oct;46(10):1589-95 PMID: 6061736
Acetyl transport mechanisms in the nervous system. The oxoglutarate shunt and fatty acid synthesis in the developing rat brain.
J Neurochem. 1968 Apr;15(4):315-23 PMID: 5644208
Coenzyme A transferase activity in rat brain.
Biochem Biophys Res Commun. 1971 Apr 2;43(1):225-31 PMID: 5579946
Enzymes of ketone-body utilisation in human brain.
Lancet. 1971 Jul 10;2(7715):66-8 PMID: 4103982
Activities of enzymes involved in acetoacetate utilization in adult mammalian tissues.
Biochem J. 1971 Jan;121(1):41-7 PMID: 5165621
Enzymes of fatty acid metabolism. IV. Preparation and properties of coenzyme A transferase.
J Biol Chem. 1956 Jul;221(1):15-31 PMID: 13345795
Ketone-body utilization by adult and suckling rat brain in vivo.
Biochem J. 1971 Mar;122(1):13-8 PMID: 5124783
A role of acetoacetyl-CoA synthetase in acetoacetate utilization by rat liver cell fractions.
Biochem Biophys Res Commun. 1971 Aug 20;44(4):1001-7 PMID: 5125223
CoA transferase in the brain and other mammalian tissues.
Arch Biochem Biophys. 1972 Feb;148(2):382-90 PMID: 5019866
Effects of starvation on normal development of -hydroxybutyrate dehydrogenase activity in foetal and newborn rat brain.
Nat New Biol. 1972 Apr 5;236(66):140-1 PMID: 4502817
Fatty acid synthetase of brain: development, influence of nutritional and hormonal factors and comparison with liver enzyme.
J Neurochem. 1972 Mar;19(3):737-53 PMID: 4402293
Removal and utilization of ketone bodies by the brain of newborn puppies.
J Neurochem. 1972 Sep;19(9):2169-73 PMID: 5072391
Activities of enzymes of ketone-body utilization in brain and other tissues of suckling rats.
Biochem J. 1971 Jan;121(1):49-53 PMID: 5116556

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1320653

Published

1973-03-00

Pages

653-6

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1177633

Subset

External Links

PubMed source DOI: 10.1042/bj1320653 PMC Full Text View journal details

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Acetoacetate and brain lipogenesis: developmental pattern of acetoacetyl-coenzyme A synthetase in the soluble fraction of rat brain.

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