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PMID: 4729042 Published · ppublish English Journal Article

Inhibition of liver fibrosis by 1-azetidine-2-carboxylic acid in rats treated with carbon tetrachloride.

The Journal of clinical investigation ·Vol. 52 ·No. 10 ·1973-10-00 ·Pages 2451-6

Rojkind M

Abstract

L-Azetidine-2-carboxylic acid (AZC), an analogue of proline, has been shown to partially ameliorate hepatic cirrhosis induced in rats by CCl(4). AZC caused a diminution in formation of collagen in the liver accompanied by a relative decrease in the pool of free proline. The synthesis of noncollagenous proteins in the livers of treated rats did not appear to be affected.

MeSH Terms
Amino Acids/pharmacology Animals Carbon Isotopes Carbon Tetrachloride Poisoning/prevention & control Collagen/biosynthesis,metabolism Hydroxylation Hydroxylysine/biosynthesis Hydroxyproline/analysis Liver/analysis,metabolism,pathology Liver Cirrhosis/chemically induced,prevention & control Male Proline/analysis,metabolism Rats Time Factors
Chemicals
Amino Acids Carbon Isotopes Hydroxylysine Collagen Proline Hydroxyproline
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Rojkind M
References (22)
22 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI107436
Published
1973-10-00
Pages
2451-6
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC302504
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI107436 PMC Full Text View journal details
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