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PMID: 4741604 Published · ppublish English Journal Article

Depression of cellular immunity in pregnancy due to a serum factor.

British medical journal ·Vol. 3 ·No. 5879 ·1973-09-08 ·Pages 513-4

Hill CA, Finn R, Denye V

Abstract

Lymphocytes from pregnant women and non-pregnant individuals were cultured under the stimulus of phytohaemagglutinin in the presence of their own and heterologous (allogeneic) sera. The results indicate that heterologous sera have an inhibitory effect on the lymphocyte transformation rate and suggest that the inhibitory property is more powerful in pregnant and fetal sera. Conversely, the addition of heterologous non-pregnant sera to cultures of pregnant lymphocytes increases their transformation rate. These findings suggest that there is a serum inhibitor in pregnancy and this finding may be relevant to the survival of the fetal allograft.

MeSH Terms
Blood Female Fetus/immunology Humans Immunity, Cellular Lectins Lymphocyte Activation Lymphocytes/immunology Pregnancy
Chemicals
Lectins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hill C A
Finn R
Denye V
References (13)
13 references, click to expand
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Article Info
Journal
British medical journal
Abbr.
Br Med J
ISSN
0007-1447
DOI
10.1136/bmj.3.5879.513
Published
1973-09-08
Pages
513-4
Language
English
Region
England
NLM ID
0372673
PMCID
PMC1586933
Subset
IM
External Links
PubMed source DOI: 10.1136/bmj.3.5879.513 PMC Full Text
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