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PMID: 4750451 Published · ppublish English Journal Article

Periodic hematopoiesis in human cyclic neutropenia.

The Journal of clinical investigation ·Vol. 52 ·No. 12 ·1973-12-00 ·Pages 3220-30

Guerry D, Dale DC, Omine M, Perry S, Wolff SM

Abstract

Human cyclic neutropenia is characterized by severe depression of blood neutrophil levels approximately every 21 days. To investigate the mechanism of cyclic neutropenia four patients were studied with daily complete blood counts, serial bone marrow examinations, marrow reserve testing, serum muramidase determinations, DF(22)P granulocytokinetic studies, and, in one patient, in vivo [(3)H]TdR labeling. Periodogram analysis of the serial blood counts in the latter patient and visual inspection of multiple cycles in the others revealed periodic fluctuations in the levels of blood neutrophils, monocytes, lymphocytes, reticulocytes, and platelets. Rhythmic changes in the morphologic and radioisotopic studies as well as the marrow reserve tests and muramidase measurements were consonant with a mechanism of periodic failure of marrow production rather than peripheral destruction. Human cyclic neutropenia is analogous to cyclic neutropenia in the grey collie dog and may be viewed as the consequence of cyclic hematopoiesis.

MeSH Terms
Agranulocytosis/blood,enzymology,physiopathology Animals Blood Cell Count Blood Platelets Bone Marrow Examination Dogs Erythrocyte Count Hematopoiesis Humans Isoflurophate Leukocyte Count Muramidase/blood Periodicity Phosphorus Radioisotopes Thymidine/blood Tritium
Chemicals
Phosphorus Radioisotopes Tritium Isoflurophate Muramidase Thymidine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Guerry D
Dale D C
Omine M
Perry S
Wolff S M
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31 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI107522
Published
1973-12-00
Pages
3220-30
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC302598
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI107522 PMC Full Text View journal details
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