Narcotic analgesics and delayed gastric emptying during labour.

Lancet (London, England) ·Vol. 1 ·No. 7912 ·1975-04-19 ·Pages 890-3

Nimmo WS, Wilson J, Prescott LF

Abstract

The rate of gastric emptying in women during labour was estimated indirectly from the kinetics of absorption of orally administered paracetamol (acetaminophen). Gastric emptying was normal in patients who had not received a narcotic analgesic but was markedly delayed in women given pethidine, diamorphine, or pentazocine. The inhibitory effect of diamorphine and pethidine on gastric emptying was not reversed by metoclopramide.

MeSH Terms

Acetaminophen/administration & dosage,blood,metabolism Administration, Oral Adolescent Adult Analgesics, Opioid/pharmacology Anesthesia, Obstetrical Female Gastrointestinal Motility/drug effects Heroin/pharmacology Humans Intestinal Absorption/drug effects Labor, Obstetric Meperidine/pharmacology Metoclopramide/pharmacology Pentazocine/pharmacology Postpartum Period Pregnancy Stomach/drug effects,physiology Time Factors

Chemicals

Analgesics, Opioid Acetaminophen Heroin Meperidine Metoclopramide Pentazocine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Nimmo W S

Wilson J

Prescott L F

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(75)91687-6

Published

1975-04-19

Pages

890-3

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(75)91687-6 View journal details

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Narcotic analgesics and delayed gastric emptying during labour.

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