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PMID: 475889 Published · ppublish English Comparative Study Journal Article

Chromosomal breakage in Crohn's disease: anticlastogenic effect of D-penicillamine and L-cysteine.

Human genetics ·Vol. 50 ·No. 1 ·1979-00-00 ·Pages 51-7

Emerit I, Emerit J, Levy A, Keck M

Abstract

The incidence of chromosome breakage was found to be elevated in 42 patients with Crohn's disease. This phenomenon was much more striking in cultures set up with TCM 199 than in cultures set up with RPMI 1629 rich in L-cysteine. The drug D-penicillamine, a close analog of L-cysteine, gave an apparent therapeutic response in several patients and reduced the chromosome breakage frequency in the lymphocytes of these patients in vitro and in vivo.

MeSH Terms
Cells, Cultured/drug effects Chromosome Aberrations Chromosomes, Human/drug effects Colitis, Ulcerative/genetics Crohn Disease/drug therapy,etiology,genetics Culture Media Cysteine/pharmacology Humans Lymphocytes/ultrastructure Penicillamine/therapeutic use
Chemicals
Culture Media Penicillamine Cysteine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Emerit I
Emerit J
Levy A
Keck M
References (12)
12 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00295589
Published
1979-00-00
Pages
51-7
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00295589 View journal details
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