The inhibition by aspirin and indomethacin of osteolytic tumor deposits and hypercalcaemia in rats with Walker tumour, and its possible application to human breast cancer.

British journal of cancer ·Vol. 28 ·No. 4 ·1973-10-00 ·Pages 316-21

Powles TJ, Clark SA, Easty DM, Easty GC, Neville AM

Abstract

Walker carcinosarcoma cells cause in vitro osteolysis which may be inhibited by aspirin. In the rat, this tumour produces osteolytic bone deposits and hypercalcaemia, both of which can be prevented by aspirin and indomethacin, whereas soft tissue tumour deposits are unaffected by these drugs. Some human breast tumours cause in vitro osteolysis which may be inhibited by aspirin.

MeSH Terms

Animals Aspirin/pharmacology Bone Neoplasms/drug therapy Bone Resorption/drug effects Bone and Bones/metabolism Breast Neoplasms/drug therapy Calcium/metabolism Calcium Radioisotopes Carcinoma 256, Walker/drug therapy Female Humans Hydrogen-Ion Concentration Hypercalcemia/prevention & control Indomethacin/pharmacology Lactates/pharmacology Mice Mice, Inbred BALB C Neoplasm Metastasis/drug therapy Time Factors

Chemicals

Calcium Radioisotopes Lactates Aspirin Calcium Indomethacin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Powles T J

Clark S A

Easty D M

Easty G C

Neville A M

References (8)

8 references, click to expand

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Effect of acetylsalicylic acid on lysosomes.
Proc Soc Exp Biol Med. 1966 Jul;122(3):634-6 PMID: 5918925
Inhibition by calcitonin of bone resorption induced in vitro by vitamin A.
Proc R Soc Lond B Biol Sci. 1968 May 14;170(1018):61-9 PMID: 4384884
Prostaglandins: stimulation of bone resorption in tissue culture.
Endocrinology. 1970 Jun;86(6):1436-40 PMID: 4315103
Invasion of cartilage by an experimental rat tumor.
Cancer Res. 1970 Aug;30(8):2252-9 PMID: 4195911
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.
Nat New Biol. 1971 Jun 23;231(25):232-5 PMID: 5284360
Hypercalcaemia in patients with advanced mammary cancer.
Br Med J. 1971 Sep 4;3(5774):573-7 PMID: 5571456
Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E 2 . A new model for the hypercalcemia of cancer.
J Exp Med. 1972 Dec 1;136(6):1329-43 PMID: 4345106

Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/bjc.1973.154

Published

1973-10-00

Pages

316-21

Language

English

Region

England

NLM ID

0370635

PMCID

PMC2008894

Subset

External Links

PubMed source DOI: 10.1038/bjc.1973.154 PMC Full Text View journal details

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The inhibition by aspirin and indomethacin of osteolytic tumor deposits and hypercalcaemia in rats with Walker tumour, and its possible application to human breast cancer.

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