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PMID: 4762763 Published · ppublish English Journal Article

Histone acetylation and hormone action. Early effects of aldosterone on histone acetylation in rat kidney.

The Biochemical journal ·Vol. 134 ·No. 4 ·1973-08-00 ·Pages 907-12

Libby PR

Abstract

Histone acetylation in the kidney of the adrenalectomized rat was increased 5 min after a physiological dose of aldosterone. The increase was exclusively in the histone F2a1. The increase in histone acetylation was given by 9alpha-fluorocortisol, deoxycorticosterone and cortisol, but not by progesterone. The increase in histone acetylation was abolished by prior treatment of the animals with the anti-mineralocorticoid agent, SC14266 [potassium 3-(3-oxo-17beta-hydroxy-4,6-androstadien-17-yl) propionate]; the basal degree of histone acetylation was unaffected. Pretreatment of the animals with actinomycin D or cyclo-heximide did not affect the stimulation, showing the stimulation was not due to increased synthesis of enzyme.

MeSH Terms
Acetates/metabolism Acetylation Adrenalectomy Aldosterone/pharmacology Animals Cycloheximide/pharmacology Dactinomycin/pharmacology Desoxycorticosterone/pharmacology Female Fludrocortisone/pharmacology Histones/metabolism Hydrocortisone/pharmacology Kidney/drug effects,metabolism Progesterone/pharmacology Rats Tritium
Chemicals
Acetates Histones Tritium Dactinomycin Desoxycorticosterone Aldosterone Progesterone Cycloheximide Fludrocortisone Hydrocortisone
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Libby P R
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23 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1340907
Published
1973-08-00
Pages
907-12
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1177899
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1340907 PMC Full Text View journal details
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