Home LiteratureArticle Details
PMID: 478640 Published · ppublish English Journal Article

Efficacy of antimicrobial therapy in experimental rat pneumonia: effects of impaired phagocytosis.

Infection and immunity ·Vol. 25 ·No. 1 ·1979-07-00 ·Pages 366-75

Bakker-Woudenberg IA, de Jong-Hoenderop JY, Michel MF

Abstract

The importance of intact host defense mechanisms for successful antimicrobial therapy was investigated in an animal model. Recovery from lobar pneumococcal pneumonia as a result of penicillin therapy was studied in normal rats and in rats treated with cobra venom factor. This factor was used to selectively suppress the phagocytosis of pneumococci as a result of complement depletion. Although complete recovery from the infection occurred in normal rats after appropriate penicillin therapy, this was not the case in cobra venom factor-treated rats. Within the limitations of this study, evidence is presented for loss of antibiotic activity as a consequence of impaired phagocytosis.

MeSH Terms
Animals Complement System Proteins/metabolism Elapid Venoms/pharmacology Female Penicillin G/therapeutic use Phagocytosis Pneumonia, Pneumococcal/drug therapy,immunology Rats
Chemicals
Elapid Venoms Complement System Proteins Penicillin G
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bakker-Woudenberg I A
de Jong-Hoenderop J Y
Michel M F
References (39)
39 references, click to expand
  1. The clinical implications of hypogammaglobul inemia in patients with chronic lymphocytic leukemia and lymphocytic lymphosarcoma.
    Ann Intern Med. 1959 Sep;51:501-16 PMID: 13840332
  2. Host-parasite relationships in experimental pneumonia due to pneumococcus type III.
    J Exp Med. 1950 Jul 1;92(1):85-100 PMID: 15422100
  3. An experimental analysis of the curative action of penicillin in acute bacterial infections. II. The role of phagocytic cells in the process of recovery.
    J Exp Med. 1956 Apr 1;103(4):499-508 PMID: 13306858
  4. Efficacy of antimicrobial therapy in experimental rat pneumonia: antibiotic treatment schedules in rats with impaired phagocytosis.
    Infect Immun. 1979 Jul;25(1):376-87 PMID: 478641
  5. Infections in patients with malignant lymphoma treated with combination chemotherapy.
    Cancer. 1977 Mar;39(3):1018-25 PMID: 912645
  6. The ability of smooth and rough strains of Streptococcus pneumoniae to activate human complement by the alternative pathway.
    J Med Microbiol. 1978 Feb;11(1):7-14 PMID: 23434
  7. The effect of complement depletion on lung clearance of bacteria.
    J Clin Invest. 1978 Aug;62(2):373-8 PMID: 27534
  8. Activation of the alternative pathway by pneumococcal cell walls.
    J Immunol. 1977 Feb;118(2):451-4 PMID: 14211
  9. Classical and alternative complement pathway activation by pneumococci.
    Infect Immun. 1977 Aug;17(2):296-302 PMID: 19357
  10. The role of membrane receptors for C3b and C3d in phagocytosis.
    J Exp Med. 1977 Feb 1;145(2):357-71 PMID: 833545
  11. Synergistic activity of carbenicillin and gentamicin in experimental Pseudomonas bacteremia in neutropenic rats.
    Antimicrob Agents Chemother. 1976 Oct;10(4):646-51 PMID: 825035
  12. Heat labile opsonins to pneumococcus. I. Participation of complement.
    J Exp Med. 1969 Dec 1;130(6):1209-27 PMID: 4390899
  13. The effect of a cobra venom factor on complement and adjuvant-induced disease in rats.
    Arthritis Rheum. 1973 Jan-Feb;16(1):71-6 PMID: 4692160
  14. Hodgkin's disease. Immunologic, clinical, and histologic features of 50 untreated patients.
    Ann Intern Med. 1967 Aug;67(2):291-302 PMID: 6036391
  15. Receptors for complement of leukocytes.
    J Exp Med. 1968 Nov 1;128(5):991-1009 PMID: 4176227
  16. Studies in vivo and in vitro on an abnormality in the metabolism of C3 in a patient with increased susceptibility to infection.
    J Clin Invest. 1970 Nov;49(11):1975-85 PMID: 4097977
  17. Heat labile opsonins to Pneumococcus. 3. The participation of immunoglobulin and of the alternate pathway of C3 activation.
    J Immunol. 1972 Jun;108(6):1681-9 PMID: 4402312
  18. Natural immunity to bacterial infections: the relation of complement to heat-labile opsonins.
    Proc Natl Acad Sci U S A. 1969 Aug;63(4):1151-6 PMID: 4390986
  19. Heat labile opsonins to pneumococcus. II. Involvement of C3 and C5.
    J Exp Med. 1969 Dec 1;130(6):1229-41 PMID: 4390900
  20. Experimental Pseudomonas pneumonia in leukopenic dogs: comparison of therapy with antibiotics and granulocyte transfusions.
    Blood. 1976 May;47(5):869-76 PMID: 816400
  21. Depletion of plasma complement in vivo by a protein of cobra venom: its effect on various immunologic reactions.
    J Immunol. 1970 Jul;105(1):55-69 PMID: 4246566
  22. Changing patterns of infection in cancer patients.
    Eur J Cancer. 1973 Jun;9(6):401-6 PMID: 4214700
  23. Proceedings: Causes of death in cancer patients.
    Cancer. 1974 Feb;33(2):568-73 PMID: 4591273
  24. Host defense against the pneumococcus in T-lymphocyte-deficient, nude mice.
    Infect Immun. 1975 Nov;12(5):1222-3 PMID: 334
  25. Pneumonia in acute leukemia.
    Ann Intern Med. 1973 Oct;79(4):528-34 PMID: 4518300
  26. Immunocompetence in advanced cancer patients prior to chemotherapy.
    Oncology. 1974;30(6):458-66 PMID: 4469028
  27. Pneumococcal bacteremia in patients with neoplastic disease.
    Cancer. 1974 Mar;33(3):845-9 PMID: 4815586
  28. Increased susceptibility to infection in a patient with type II essential hypercatabolism of C3.
    N Engl J Med. 1973 Mar 22;288(12):601-6 PMID: 4686987
  29. Recent experience with bacteremia in patients presenting cancer.
    Eur J Cancer. 1973 Jan;9(1):69-76 PMID: 4703691
  30. Antibiotic combinations for infections in neutropenic patients. Evaluaton of carbenicillin plus either cephalothin or kanamycin.
    Cancer. 1972 Aug;30(2):573-9 PMID: 5051680
  31. Studies in vivo of cobra factor and murine C3.
    Immunology. 1975 Feb;28(2):369-77 PMID: 804439
  32. Infections in cancer patients.
    Cancer Treat Rev. 1975 Jun;2(2):89-128 PMID: 1102088
  33. Effects of cytotoxic and immunosuppressive agents on the immune system.
    Postgrad Med. 1975 Dec;58(7):67-74 PMID: 1105494
  34. Influence of immunosuppression on the action of antimycobacterial drugs in experimental tuberculosis. I. Effects of isoniazid, rifampicin and streptomycin on the survival of tuberculous mice immunosuppressed by azathioprine (Imuran).
    Chemotherapy. 1976;22(6):353-61 PMID: 954481
  35. Complement system in pneumococcal infections.
    Infect Immun. 1976 Apr;13(4):1120-5 PMID: 1279001
  36. The role of C3 as an opsonin in the early stages of infection.
    Proc Soc Exp Biol Med. 1975 Jun;149(2):397-401 PMID: 1153415
  37. Leukocyte function in patients with leukemia.
    Cancer. 1970 Apr;25(4):835-42 PMID: 5266560
  38. Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia.
    Ann Intern Med. 1966 Feb;64(2):328-40 PMID: 5216294
  39. Study of bactericidal and bacteriostatic antibiotics in animals with normal and suppressed immunity.
    Chemotherapy. 1968;13(2):100-7 PMID: 5656115
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.25.1.366-375.1979
Published
1979-07-00
Pages
366-75
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC414461
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.25.1.366-375.1979 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2