Tobramycin and gentamicin concentrations in the serum of normal and anephric patients.

Antimicrobial agents and chemotherapy ·Vol. 3 ·No. 1 ·1973-01-00 ·Pages 125-9

Lockwood WR, Bower JD

Abstract

The serum half-life of tobramycin was found to be the same as that of gentamicin in patients with similar renal function. The values ranged from 2 hr in normal volunteers to 53.4 hr in anephric patients. Both drugs were readily removed from the serum by the Kiil artificial kidney, with a 70% reduction in serum concentrations during a 12-hr dialysis period.

MeSH Terms

Aminoglycosides/blood Anti-Bacterial Agents/blood Gentamicins/blood Half-Life Humans Kidney/physiology Kidney Diseases/blood Nephrectomy

Chemicals

Aminoglycosides Anti-Bacterial Agents Gentamicins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lockwood W R

Bower J D

References (18)

18 references, click to expand

Evaluation of the in vitro activity of tobramycin as compared with that of gentamicin sulfate.
Appl Microbiol. 1972 Jan;23(1):4-7 PMID: 4621796
Dose of gentamicin in patients with normal renal function and renal impairment.
Br Med J. 1968 Apr 6;2(5596):19-22 PMID: 20791473
Gentamicin dosages for renal insufficiency. Adjustments based on endogenous creatinine clearance and serum creatinine concentration.
Ann Intern Med. 1971 Feb;74(2):192-7 PMID: 4993502
Blood levels of ampicillin, kanamycin and gentamicin in the uremic patient.
Isr J Med Sci. 1970 Nov-Dec;6(6):683-90 PMID: 5512589
In vitro studies of tobramycin, an aminoglycoside antibiotic.
Antimicrob Agents Chemother. 1972 Jan;1(1):41-5 PMID: 4670427
In vitro susceptibility testing with tobramycin.
Antimicrob Agents Chemother. 1972 May;1(5):412-6 PMID: 4670483
In vitro evaluation of tobramycin, a new aminoglycoside antibiotic.
Antimicrob Agents Chemother. 1972 May;1(5):381-4 PMID: 4670478
Rapid microassay for circulating nephrotoxic antibiotics.
Antimicrob Agents Chemother (Bethesda). 1970;10:83-90 PMID: 5000271
Preclinical assessment of the antibacterial activity of nebramycin factor 6.
Antimicrob Agents Chemother (Bethesda). 1970;10:322-7 PMID: 4939737
Correlation of serum creatinine concentration and gentamicin half-life.
JAMA. 1972 Feb 21;219(8):1037-41 PMID: 5066760
Parenteral administration of gentamicin in renal failure: patients undergoing intermittent haemodialysis.
Br Med J. 1967 May 27;2(5551):537-9 PMID: 6023987
Tobramycin (nebramycin factor 6): in vitro activity against Pseudomonas aeruginosa.
Appl Microbiol. 1971 Dec;22(6):1147-51 PMID: 5002900
Tobramycin: in vitro activity and comparison with kanamycin and gentamicin.
Antimicrob Agents Chemother. 1972 Apr;1(4):340-2 PMID: 4670697
Preliminary studies with nebramycin factor 6.
Antimicrob Agents Chemother (Bethesda). 1970;10:314-21 PMID: 5521350
Pharmacologic studies on tobramycin and comparison with gentamicin.
J Clin Pharmacol New Drugs. 1972 Aug-Sep;12(8):321-4 PMID: 4484032
A guide to use of antibiotics in patients with renal disease. A table of recommended doses and factors governing serum levels.
Ann Intern Med. 1967 Jul;67(1):151-8 PMID: 6028645
GENTAMICIN: ACTIVITY IN VITRO AND OBSERVATIONS IN 26 PATIENTS.
Am J Med Sci. 1964 Nov;248:528-44 PMID: 14224772
Cross-resistance of Pseudomonas to gentamicin and tobramycin.
Antimicrob Agents Chemother. 1972 Mar;1(3):280-1 PMID: 4625628

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.3.1.125

Published

1973-01-00

Pages

125-9

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC444371

Subset

External Links

PubMed source DOI: 10.1128/AAC.3.1.125 PMC Full Text View journal details

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Tobramycin and gentamicin concentrations in the serum of normal and anephric patients.

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