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PMID: 4791301 Published · ppublish English Journal Article

Biosynthesis of monensin.

Antimicrobial agents and chemotherapy ·Vol. 4 ·No. 4 ·1973-10-00 ·Pages 410-4

Day LE, Chamberlin JW, Gordee EZ, Chen S, Gorman M, Hamill RL, Ness T, Weeks RE, Stroshane R

Abstract

The biosynthesis of monensin by Streptomyces cinnamonensis was studied by using (14)C-labeled glucose, acetate, propionate, butyrate, and methionine. The results indicated that the antibiotic is synthesized from five acetate, seven propionate, and one butyrate molecules. The o-methyl group of monensin is derived from methionine, whereas the terminal hydroxymethyl group is incorporated from acetate.

MeSH Terms
Anti-Bacterial Agents/biosynthesis Carbon Radioisotopes Fatty Acids, Volatile/metabolism Furans/biosynthesis Pyrans/biosynthesis Streptomyces/metabolism
Chemicals
Anti-Bacterial Agents Carbon Radioisotopes Fatty Acids, Volatile Furans Pyrans
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Day L E
Chamberlin J W
Gordee E Z
Chen S
Gorman M
Hamill R L
Ness T
Weeks R E
Stroshane R
References (5)
5 references, click to expand
  1. Monensin, a new biologically active compound. I. Discovery and isolation.
    Antimicrob Agents Chemother (Bethesda). 1967;7:349-52 PMID: 5596158
  2. Monensin, a new biologically active compound. II. Fermentation studies.
    Antimicrob Agents Chemother (Bethesda). 1967;7:353-8 PMID: 5596159
  3. Monensin, a new biologically active compound. IV. Chemistry.
    Antimicrob Agents Chemother (Bethesda). 1967;7:359-62 PMID: 5596160
  4. The biosynthesis of the macrolide antibiotic lucensomycin.
    J Antibiot (Tokyo). 1969 Nov;22(11):545-50 PMID: 5364432
  5. The structure of monensic acid, a new biologically active compound.
    J Am Chem Soc. 1967 Oct 25;89(22):5737-9 PMID: 5622366
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.4.4.410
Published
1973-10-00
Pages
410-4
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC444568
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.4.4.410 PMC Full Text View journal details
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