Enzymatic acetylation as a means of determining serum aminoglycoside concentrations.

Antimicrobial agents and chemotherapy ·Vol. 4 ·No. 4 ·1973-10-00 ·Pages 497-9

Haas MJ, Davies J

Abstract

A rapid and accurate enzymatic assay has been developed for the determination of blood serum levels of BB-K8 and other suitable aminoglycoside antibiotics.

MeSH Terms

Acetyl Coenzyme A Acetyltransferases Aminoglycosides/blood Anti-Bacterial Agents/blood Carbon Radioisotopes Humans Kanamycin Methods

Chemicals

Aminoglycosides Anti-Bacterial Agents Carbon Radioisotopes Kanamycin Acetyl Coenzyme A Acetyltransferases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Haas M J

Davies J

References (5)

5 references, click to expand

Chloramphenicol-, dihydrostreptomycin-, and kanamycin-inactivating enzymes from multiple drug-resistant Escherichia coli carrying episome 'R'.
Nature. 1965 Dec 25;208(5017):1301-3 PMID: 4161995
Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli.
J Antibiot (Tokyo). 1967 Jul;20(3):136-41 PMID: 4863032
Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor.
Biochemistry. 1971 May 11;10(10):1787-96 PMID: 4935296
A rapid chemical assay for gentamicin.
N Engl J Med. 1972 Mar 16;286(11):583-6 PMID: 4550890
Gentamicin resistance in strains of Pseudomonas aeruginosa mediated by enzymatic N-acetylation of the deoxystreptamine moiety.
Biochemistry. 1972 Feb 29;11(5):761-5 PMID: 4621822

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.4.4.497

Published

1973-10-00

Pages

497-9

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC444583

Subset

External Links

PubMed source DOI: 10.1128/AAC.4.4.497 PMC Full Text View journal details

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Enzymatic acetylation as a means of determining serum aminoglycoside concentrations.

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