Successful treatment of Pseudomonas cepacia endocarditis with trimethoprim-sulfamethoxazole.
A patient with a history of alcoholism and drug abuse who developed Pseudomonas cepacia endocarditis is described. The organism was found to be resistant in vitro to all common antimicrobial agents except chloramphenicol and trimethoprim-sulfamethoxazole. Treatment failed with penicillin and streptomycin and later with chloramphenicol. Orally administered trimethoprim-sulfamethoxazole, however, resulted in sterilization of the patient's blood and aortic valve which was resected 27 days after the start of therapy. A 6-week course of therapy was completed and, to date (6 months after treatment), there has been no recurrence.
18 references, click to expand
-
Surgical management of the complications of sepsis involving the aortic valve, aortic root, and ascending aorta.Ann Thorac Surg. 1971 Oct;12(4):391-9 PMID: 4939118
-
Trimethoprim, a sulphonamide potentiator.Br J Pharmacol Chemother. 1968 May;33(1):72-90 PMID: 5301731
-
Flavobacterium infection as a cause of bacterial endocarditis. Report of a case, bacteriologic studies, and review of the literature.Ann Intern Med. 1961 Sep;55:499-506 PMID: 13747611
-
Colonization and infection with Pseudomonas cepacia.J Infect Dis. 1972 Jun;125(6):613-8 PMID: 5037014
-
Pseudomonas cepacia endocarditis treated with co-trimoxazole and kanamycin.Br Heart J. 1973 Jan;35(1):47-8 PMID: 4685906
-
Trimethoprim: laboratory and clinical studies.J Clin Pathol. 1968 Mar;21(2):202-9 PMID: 5697054
-
Esch. coli endocarditis successfully treated with oral trimethoprim and sulphamethoxazole.Br Heart J. 1970 Jan;32(1):127-9 PMID: 4907123
-
Acute bacterial endocarditis caused by a variant of the genus Herrellea.Am J Clin Pathol. 1952 Feb;23(2):134-8 PMID: 13016518
-
Combined antibacterial action in vitro of trimethoprim and sulphonamides. The in vitro nature of synergy.Postgrad Med J. 1969 Nov;45:Suppl:10-8 PMID: 5361305
-
Etiology of bacterial endocarditis. Before and since the introduction of antibiotics.Ann Intern Med. 1963 Jun;58:946-52 PMID: 14001062
-
The major medical complications of heroin addiction.Ann Intern Med. 1967 Jul;67(1):1-22 PMID: 5339228
-
Pulmonary and cardiovascular implications of drug addiction.Ann Thorac Surg. 1973 Mar;15(3):263-74 PMID: 4266158
-
Infective endocarditis in narcotic addicts.Ann Intern Med. 1968 Dec;69(6):1091-8 PMID: 5710389
-
Aortic insufficiency in bacterial endocarditis.Ann Intern Med. 1972 Jan;76(1):23-8 PMID: 5021551
-
Infrequently encountered Pseudomonas species causing infection in humans.Ann Intern Med. 1972 Aug;77(2):211-5 PMID: 4641655
-
Favorable experience with bacterial endocarditis in heroin addicts.Ann Intern Med. 1973 Jan;78(1):25-32 PMID: 4539327
-
Operative management of valvular complications of bacterial endocarditis.J Thorac Cardiovasc Surg. 1972 Aug;64(2):235-46 PMID: 5048378
-
Cardiac surgery in bacterial endocarditis.J Thorac Cardiovasc Surg. 1972 Aug;64(2):282-90 PMID: 5048383
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
