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PMID: 4793332 Published · ppublish English Journal Article

Effects of chlorpromazine on exploration and habituation in the rat.

British journal of pharmacology ·Vol. 49 ·No. 2 ·1973-10-00 ·Pages 303-10

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Abstract

1. The effects of chlorpromazine, 2 and 4 mg/kg, on exploration were investigated under two independent influences-food deprivation and time of day.2. Rats had three 3-minute trials in a hole-board apparatus; hole-investigation (head-dips) and general motor activity were recorded.3. On trial 1 chlorpromazine reduced exploration to half the control level, but on trial 3 it had no effect on motor activity or head-dips.4. General activity habituated from trial 1 to 3 in all groups, but some of the drug groups did not show significant habituation of head-dips, due to the low level of responding on trial 1.

MeSH Terms
Animals Ataxia/chemically induced Chlorpromazine/administration & dosage,pharmacology Circadian Rhythm Exploratory Behavior/drug effects Food Deprivation Habituation, Psychophysiologic/drug effects Locomotion/drug effects Male Motor Activity/drug effects Movement/drug effects Rats
Chemicals
Chlorpromazine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
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References (22)
22 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1973.tb08376.x
Published
1973-10-00
Pages
303-10
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1776385
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1973.tb08376.x PMC Full Text View journal details
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