Regulation of human lipolysis. In vivo observations on the role of adrenergic receptors.

The Journal of clinical investigation ·Vol. 53 ·No. 1 ·1974-01-00 ·Pages 338-41

Burns TW, Mohs JM, Langley PE, Yawn R, Chase GR

Abstract

Changes in the plasma free fatty acids of a pancreatectomized subject and in free fatty acids and insulin in 10 normal subjects in response to the in vivo infusion of epinephrine alone, epinephrine plus phentolamine, and epinephrine plus propranolol indicate that both alpha and beta adrenergic receptors are present in human adipose tissue. Under the experimental conditions used, adipose tissue appeared to be more responsive to epinephrine than did the cardiovascular system.

MeSH Terms

Adipose Tissue/drug effects Adult Blood Glucose/metabolism Blood Pressure/drug effects Epinephrine/administration & dosage,pharmacology Fatty Acids, Nonesterified/blood Glycerol/blood Humans Insulin/blood Male Pancreatectomy Phentolamine/administration & dosage,pharmacology Propranolol/administration & dosage,pharmacology Time Factors

Chemicals

Blood Glucose Fatty Acids, Nonesterified Insulin Propranolol Glycerol Epinephrine Phentolamine

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Burns T W

Mohs J M

Langley P E

Yawn R

Chase G R

References (10)

10 references, click to expand

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An adrenergic receptor mechanism for the control of cyclic 3'5' adenosine monophosphate synthesis in tissues.
Biochem Biophys Res Commun. 1967 Sep 7;28(5):797-802 PMID: 4861257
Lipolysis by human adipose tissue: the role of cyclic 3',5'-adenosine monophosphate and adrenergic receptor sites.
J Lab Clin Med. 1970 Jun;75(6):983-97 PMID: 4316106
Sympathin E, sympathin I, and the intracellular level of cyclic AMP.
Circ Res. 1970 Jul;27(1 Suppl 1):147-61 PMID: 4393715
Potassium ion release and enzyme secretion: adrenergic regulation by alpha- and beta-receptors.
Science. 1971 Dec 3;174(4013):1029-31 PMID: 4399182
Adrenergic receptors in human adipocytes--divergent effects of adenosine 3',5'-monophosphate and lipolysis.
Biochem Pharmacol. 1972 Feb 15;21(4):589-92 PMID: 4335408
Adrenergic receptor response in hypothyroidism. An in vitro study on human adipose tissue and rabbit aorta.
Acta Med Scand Suppl. 1972;532:1-28 PMID: 4343703
A rapid enzymatic assay for glycerol.
Nature. 1962 Dec 8;196:987-8 PMID: 13946593
Immunoassay of insulin with insulin-antibody precipitate.
Biochem J. 1963 Jul;88:137-46 PMID: 13952078
Titration of free fatty acids of plasma: a study of current methods and a new modification.
J Lipid Res. 1960 Apr;1:199-202 PMID: 13839500

Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI107556

Published

1974-01-00

Pages

338-41

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC301470

Subset

External Links

PubMed source DOI: 10.1172/JCI107556 PMC Full Text View journal details

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Regulation of human lipolysis. In vivo observations on the role of adrenergic receptors.

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