Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate.

The Biochemical journal ·Vol. 138 ·No. 2 ·1974-02-00 ·Pages 313-6

Halestrap AP, Denton RM

Abstract

alpha-Cyano-4-hydroxycinnamate greatly inhibits the transport of pyruvate but not that of acetate or butyrate in liver mitochondria and erythrocytes. In the latter, lactate uptake is also inhibited. It is concluded that a specific carrier is involved in membrane transport of pyruvate and that the plasma-membrane carrier may also be involved in lactate transport.

MeSH Terms

Acetates/metabolism Animals Biological Transport, Active/drug effects Butyrates/metabolism Carbon Radioisotopes Cell Membrane/metabolism Cinnamates/pharmacology Coumaric Acids Erythrocytes/cytology,drug effects,metabolism Humans Lactates/metabolism Membranes/metabolism Mitochondria, Liver/drug effects,metabolism Nitriles/pharmacology Organ Specificity Pyruvates/blood,metabolism Rats Species Specificity Tritium

Chemicals

Acetates Butyrates Carbon Radioisotopes Cinnamates Coumaric Acids Lactates Nitriles Pyruvates Tritium alpha-cyano-4-hydroxycinnamate

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Halestrap A P

Denton R M

References (8)

8 references, click to expand

Mitochondria metabolite transport.
FEBS Lett. 1970 Feb 16;6(3):145-154 PMID: 11947361
The sensitivity of dicarboxylate anion exchange reactions o transport inhibitors in rat-liver mitochondria.
Biochim Biophys Acta. 1970 Aug 4;216(1):63-70 PMID: 5497191
The transport of pyruvate in rat liver mitochondria.
FEBS Lett. 1971 Jan 30;12(5):285-288 PMID: 11945601
Pyruvate uptake in rat liver mitochondria: Transport or adsorption?
FEBS Lett. 1972 Mar;21(1):11-13 PMID: 11946462
Kinetics of succinate uptake by rat-liver mitochondria.
FEBS Lett. 1969 Aug;4(4):251-254 PMID: 11947195
Evidence for the existence of a pyruvate permease in rat-heart muscle.
Biochem J. 1967 Sep;104(3):51P PMID: 6049884
Adenine nucleotide translocation of mitochondria. 1. Specificity and control.
Eur J Biochem. 1968 Oct 17;6(1):66-79 PMID: 5725814
Metabolite transport in mitochondria: an example for intracellular membrane function.
Essays Biochem. 1970;6:119-59 PMID: 5499232

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1380313

Published

1974-02-00

Pages

313-6

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1166210

Subset

External Links

PubMed source DOI: 10.1042/bj1380313 PMC Full Text View journal details

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Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate.

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