Genetic mapping of Ir locus in man: linkage to second locus of HL-A.

Science (New York, N.Y.) ·Vol. 184 ·No. 4143 ·1974-06-21 ·Pages 1301-3

Blumenthal MN, Amos DB, Noreen H

Abstract

Fifty-seven members of a family that spanned three generations were studied for antigen E and ragweed skin sensitivity and HL-A antigens. There was significant association between the haplotype HL-A 2-12 and antigen E skin hypersensitivity (F = .22 to .26) in this family. The map order is first locus of HL-A, second locus of HL-A, and IrE. These determinants are considered to be part of the linkage group HL-1.

MeSH Terms

Adolescent Adult Aged Allergens Child Chromosome Mapping Female Genetic Linkage Histocompatibility Antigens Humans Hypersensitivity/genetics,immunology Lymphocytes/immunology Male Middle Aged Pedigree Phenotype Pollen Recombination, Genetic Skin Tests

Chemicals

Allergens Histocompatibility Antigens

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Blumenthal M N

Amos D B

Noreen H

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.184.4143.1301

Published

1974-06-21

Pages

1301-3

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.184.4143.1301 View journal details

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Genetic mapping of Ir locus in man: linkage to second locus of HL-A.

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