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PMID: 4834369 Published · ppublish English Journal Article

Platelet and plasma fibrinogens are identical gene products.

Science (New York, N.Y.) ·Vol. 185 ·No. 4148 ·1974-07-26 ·Pages 368-70

Doolittle RF, Takagi T, Cottrell BA

Abstract

Human platelet fibrinogen has been shown to be indistinguishable from plasma fibrinogen by a variety of criteria, including subunit composition and cross-linking characteristics as judged by sodium dodecyl sulfate-gel electro phoresis, quantitative amino terminal analysis of fibrin, and the amino acid compositions of fibrinopeptides released from platelet and plasma fibrinogens is products of the same gene or genes.

MeSH Terms
Amino Acid Sequence Amino Acids/analysis Blood Platelets/metabolism Electrophoresis, Polyacrylamide Gel Fibrin/analysis Fibrinogen/analysis,biosynthesis Genes Genetic Code Humans Peptides/analysis,isolation & purification Protein Biosynthesis Protein Conformation Sodium Dodecyl Sulfate
Chemicals
Amino Acids Peptides Sodium Dodecyl Sulfate Fibrin Fibrinogen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Doolittle R F
Takagi T
Cottrell B A
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
Published
1974-07-26
Pages
368-70
Language
English
Region
United States
NLM ID
0404511
Subset
IM
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