Comparative trial of benzhexol, amantadine, and levodopa in the treatment of Parkinson's disease.

Journal of neurology, neurosurgery, and psychiatry ·Vol. 37 ·No. 4 ·1974-04-00 ·Pages 422-6

Parkes JD, Baxter RC, Marsden CD, Rees JE

Abstract

Fourteen slightly disabled patients with Parkinsonism were treated separately with benzhexol, amantadine, and levodopa. Benzhexol and amantadine both gave a 15% reduction in functional disability and levodopa a 36% reduction. Benzhexol lessened the rigidity and improved the flexion of posture of Parkinson's disease, but had little or no effect on akinesia and tremor. Amantadine and levodopa caused improvement in all these symptoms. The combination of benzhexol and amantadine was as effective after four weeks of treatment as levodopa was after six months.

MeSH Terms

Aged Amantadine/administration & dosage,adverse effects,therapeutic use Cognition Disorders/chemically induced Dihydroxyphenylalanine/adverse effects,therapeutic use Drug Therapy, Combination Edema/chemically induced Eye Movements Female Humans Male Middle Aged Movement Disorders/chemically induced Parkinson Disease/drug therapy Parkinson Disease, Postencephalitic/drug therapy Trihexyphenidyl/administration & dosage,adverse effects,therapeutic use Xerostomia/chemically induced

Chemicals

Dihydroxyphenylalanine Trihexyphenidyl Amantadine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Parkes J D

Baxter R C

Marsden C D

Rees J E

References (15)

15 references, click to expand

Cholinergic-anticholinergic antagonism in parkinsonism.
Arch Neurol. 1967 Aug;17(2):124-36 PMID: 4382112
Modification of Parkinsonism--chronic treatment with L-dopa.
N Engl J Med. 1969 Feb 13;280(7):337-45 PMID: 4178641
Amantadine HCL (Symmetrel) and its relation to Levo-Dopa in the treatment of Parkinson's disease.
Trans Am Neurol Assoc. 1969;94:85-90 PMID: 4907453
Amantadine in Parkinsonism.
Lancet. 1970 Nov 21;2(7682):1091-2 PMID: 4098392
On the mode of action of amantadine.
J Pharm Pharmacol. 1970 Dec;22(12):959-62 PMID: 4395528
Increased synthesis and release of dopamine in the striatum of the rat after amantadine treatment.
Eur J Pharmacol. 1970;13(1):131-3 PMID: 5496921
L-dopa and amantadine hydrochloride in Parkinson's disease.
Int Z Klin Pharmakol Ther Toxikol. 1971 Apr;4(3):356-60 PMID: 4931417
Levodopa in Parkinsonism: the effects of withdrawal of anticholinergic drugs.
Br Med J. 1971 May 29;2(5760):487-91 PMID: 5579489
Idiopathic Parkinsonism treated with an extracerebral decarboxylase inhibitor in combination with levodopa.
Br Med J. 1971 Sep 25;3(5777):729-32 PMID: 4938431
The continued use of amantadine hydrochloride in parkinsonism.
Med J Aust. 1971 Oct 2;2(14):707-9 PMID: 4939890
Dopamine and noradrenaline releasing action of amantadine in the central and peripheral nervous system: a possible mode of action in Parkinson's disease.
Eur J Pharmacol. 1971 Sep;16(1):27-38 PMID: 5157529
[Amantadine. Prolonged clinical trial in 50 parkinsonian patients].
Nouv Presse Med. 1972 Feb 19;1(8):533-6 PMID: 5012351
Drug therapy of parkinsonism.
N Engl J Med. 1972 Jul 6;287(1):20-4 PMID: 4555145
Treatment of Parkinson's disease with levodopa combined with L-alpha-methyldopahydrazine, an inhibitor of extracerebral DOPA decarboxylase.
J Neurol Neurosurg Psychiatry. 1973 Feb;36(1):10-4 PMID: 4691682
A REVIEW OF DRUG THERAPY IN PARKINSONISM.
Bull N Y Acad Med. 1965 Aug;41:898-910 PMID: 14320529

Article Info

Journal

Journal of neurology, neurosurgery, and psychiatry

Abbr.

J Neurol Neurosurg Psychiatry

ISSN

0022-3050

DOI

10.1136/jnnp.37.4.422

Published

1974-04-00

Pages

422-6

Language

English

Region

England

NLM ID

2985191R

PMCID

PMC494673

Subset

External Links

PubMed source DOI: 10.1136/jnnp.37.4.422 PMC Full Text View journal details

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Comparative trial of benzhexol, amantadine, and levodopa in the treatment of Parkinson's disease.

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