Quantitative studies on tumor enhancement in mice. I. Enhancement of sarcoma I induced by IgM, IgG1, and IgG2.

The Journal of experimental medicine ·Vol. 140 ·No. 2 ·1974-08-01 ·Pages 591-6

Rubinstein P, Decary F, Streun EW

Abstract

The concentration of specific alloantibody in purified mouse immunoglobulin preparations was determined. When passively transferred in adequate doses, IgM, IgG1, and IgG2 antibodies all induced tumor enhancement in allogeneic hosts. IgM and IgG2 antibodies in high concentration led to inhibition of tumor growth. IgM and either IgG1 or IgG2 had additive effects on tumor enhancement. IgG1, but not IgG2, suppressed the inhibitory effect of IgM in high concentration.

MeSH Terms

Animals Antibody Formation Ascitic Fluid/analysis Chromatography, DEAE-Cellulose Chromatography, Gel Electrophoresis Female Immunization, Passive Immunoglobulin G/analysis Immunoglobulin M/analysis Iodine Radioisotopes Isoantibodies/analysis Male Mice Mice, Inbred C57BL Neoplasm Transplantation Radioimmunoassay Sarcoma, Experimental/immunology,pathology Spleen/cytology,immunology Transplantation Immunology Transplantation, Homologous

Chemicals

Immunoglobulin G Immunoglobulin M Iodine Radioisotopes Isoantibodies

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Rubinstein P

Decary F

Streun E W

References (11)

11 references, click to expand

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Adv Immunol. 1972;15:167-214 PMID: 4404339
Immunochemical and biologic characterization of alloantibody active in immunologic enhancement.
Transplant Proc. 1973 Mar;5(1):585-7 PMID: 4695953
Immunological tumor enhancement and in vitro cytotoxicity. Further evidence for the involvement of 7S 2a-immunoglobulin.
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Transplantation. 1974 Jan 1;17(1):121 PMID: 4809198
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Prog Allergy. 1971;15:328-485 PMID: 4151281
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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.140.2.591

Published

1974-08-01

Pages

591-6

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2139585

Subset

External Links

PubMed source DOI: 10.1084/jem.140.2.591 PMC Full Text View journal details

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Quantitative studies on tumor enhancement in mice. I. Enhancement of sarcoma I induced by IgM, IgG1, and IgG2.

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