Effects of the cyanine dye 3,3'-dipropylthiocarbocyanine on mitochondrial energy conservation.

The Biochemical journal ·Vol. 180 ·No. 3 ·1979-06-15 ·Pages 669-72

Howard PH, Wilson SB

Abstract

Mitochondrial respiration and oxidative phosphorylation were inhibited by the membrane potential probe 3,3'-dipropylthiocarbocyanine [diS-C3-(5)]. Evidence is presented that suggests that the dye acts as both an inhibitor of electron transport and an uncoupler of oxidative phosphorylation.

MeSH Terms

Animals Brassica/metabolism Carbocyanines/pharmacology Coloring Agents/pharmacology Electron Transport/drug effects In Vitro Techniques Mitochondria/drug effects,metabolism Mitochondria, Liver/drug effects,metabolism Oxidative Phosphorylation/drug effects Oxygen Consumption/drug effects Quinolines/pharmacology Rats

Chemicals

Carbocyanines Coloring Agents Quinolines

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Howard P H

Wilson S B

References (18)

18 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1800669

Published

1979-06-15

Pages

669-72

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1161108

Subset

External Links

PubMed source DOI: 10.1042/bj1800669 PMC Full Text View journal details

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Effects of the cyanine dye 3,3'-dipropylthiocarbocyanine on mitochondrial energy conservation.

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