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PMID: 4866448 Published · ppublish English Journal Article Review

Some principles of the immunology of trypanosomiasis.

Bulletin of the World Health Organization ·Vol. 37 ·No. 2 ·1967-00-00 ·Pages 177-93

Gray AR

Abstract

Although immunological methods have not been used on a wide scale for the study of trypanosomiasis in Africa, there is hope that immunological research will lead to improved methods of diagnosis, methods for the classification of trypanosome strains, better understanding of the epidemiology, epizootiology and pathology of trypanosomiasis, and ultimately the development of methods of immunization against the disease.This paper reviews some of the problems that hinder progress in each of these areas. Such problems include inadequacies in existing methods of obtaining antigens of Trypanosoma vivax, T. congolense, and T. gambiense; the general lack of fundamental information on the nature and properties of trypanosome antigens; and the variability of certain trypanosome antigens in infected animals. Recent progress towards the solution of these problems is summarized, and aspects of the immunology of trypanosomiasis that require further study are discussed. These include the diagnostic value of determinations of IgM globulin levels; the properties of T. vivax and T. congolense antigens; the natural immunity of game animals and certain varieties of cattle to trypanosomiasis; and the possibility of immunizing livestock by exposing drug-treated animals to a continuous low-grade trypanosome challenge.

MeSH Terms
Africa Animals Antigens Cattle Complement Fixation Tests Humans Immunization Mice Mutation Precipitin Tests Rats Trypanosoma/classification Trypanosomiasis/diagnosis,immunology,veterinary Trypanosomiasis, Bovine
Chemicals
Antigens
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Gray A R
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Article Info
Journal
Bulletin of the World Health Organization
Abbr.
Bull World Health Organ
ISSN
0042-9686
Published
1967-00-00
Pages
177-93
Language
English
Region
Switzerland
NLM ID
7507052
PMCID
PMC2554338
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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