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PMID: 4881422 Published · ppublish English Journal Article

Morphology of the nucleoprotein component of rabies virus.

Journal of virology ·Vol. 2 ·No. 10 ·1968-10-00 ·Pages 1191-9

Hummeler K, Tomassini N, Sokol F, Kuwert E, Koprowski H

Abstract

The intracytoplasmic ground substance, or matrix, associated with the development of rabies virus and the nucleocapsid of the virus were investigated. The filaments of the matrix were identified as virus-specific by means of ferritin-labeled antibodies. In thin sections, the diameter was 15 nm and the strands seemed to be incorporated into virions during morphogenesis of the virus. The nucleocapsid was isolated from purified virus preparations and was studied in negative contrast. The rabies nucleocapsid appeared as a single-stranded helix with a diameter of 16 nm and a periodicity of 7.5 nm; its length was in excess of 1 mum.

MeSH Terms
Chemical Phenomena Chemistry Culture Techniques Cytoplasm/analysis Ferritins Fluorescent Antibody Technique Microscopy, Electron Morphogenesis Nucleoproteins/analysis Rabies virus/growth & development
Chemicals
Nucleoproteins Ferritins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hummeler K
Tomassini N
Sokol F
Kuwert E
Koprowski H
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.2.10.1191-1199.1968
Published
1968-10-00
Pages
1191-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC375452
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.2.10.1191-1199.1968 PMC Full Text View journal details
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