Erythromycin-resistant mutant of Escherichia coli with altered ribosomal protein component.

Science (New York, N.Y.) ·Vol. 162 ·No. 3853 ·1968-11-01 ·Pages 576-8

Tanaka K, Teraoka H, Tamaki M, Otaka E, Osawa S

Abstract

Erythromycin combines with 50S ribosomal subunit of an erythromycin-sensitive Escherichia coli (strain Q13), while ribosomes from an erythromycin-resistant mutant from this strain have little affinity for the antibiotic. A protein component of the 50S subunit of the mutant strain is distinct from that of the parent Q13 strain.

MeSH Terms

Bacterial Proteins/analysis Carbon Isotopes Cell-Free System Chromatography, Ion Exchange Drug Resistance, Microbial Erythromycin/metabolism Escherichia coli/cytology,drug effects,metabolism Genetics, Microbial Lysine Methylcellulose Mutation Pharmacogenetics Protein Binding Ribosomes/metabolism Tritium Tryptophan

Chemicals

Bacterial Proteins Carbon Isotopes Tritium Erythromycin Tryptophan Methylcellulose Lysine

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Tanaka K

Teraoka H

Tamaki M

Otaka E

Osawa S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.162.3853.576

Published

1968-11-01

Pages

576-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.162.3853.576 View journal details

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Erythromycin-resistant mutant of Escherichia coli with altered ribosomal protein component.

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