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PMID: 4887508 Published · ppublish English Journal Article

Repression of the histidine operon: effect of the first enzyme on the kinetics of repression.

Journal of bacteriology ·Vol. 97 ·No. 3 ·1969-03-00 ·Pages 1283-90

Kovach JS, Berberich MA, Venetianer P, Goldberger RF

Abstract

Kinetic studies on repression of the enzymes for histidine biosynthesis in Salmonella typhimurium showed that, upon addition of histidine to a derepressed culture, the enzymes became repressed in a temporal sequence which corresponds with the positional sequence of the genes in the histidine operon. This serial pattern of repression occurred under conditions in which the feedback site of the first enzyme for histidine biosynthesis is intact. When this site was rendered nonfunctional the pattern of repression was changed so that all of the enzymes became repressed concomitantly. These results suggest that the first enzyme for histidine biosynthesis plays a hitherto unrecognized role in control of the histidine system.

MeSH Terms
Enzyme Repression Enzymes/metabolism Feedback Genetics, Microbial Histidine/biosynthesis,pharmacology Molecular Biology Mutation Operon Salmonella typhimurium/enzymology,metabolism
Chemicals
Enzymes Histidine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kovach J S
Berberich M A
Venetianer P
Goldberger R F
References (26)
26 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.97.3.1283-1290.1969
Published
1969-03-00
Pages
1283-90
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC249845
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.97.3.1283-1290.1969 PMC Full Text View journal details
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