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PMID: 4887510 Published · ppublish English Journal Article

Cold-sensitive mutations in Salmonella typhimurium which affect ribosome synthesis.

Journal of bacteriology ·Vol. 97 ·No. 3 ·1969-03-00 ·Pages 1298-304

Tai PC, Kessler DP, Ingraham J

Abstract

A number of mutations (45) expressed as cold-sensitive conditional lethal pheno-types were screened by transduction for their linkage to the streptomycin-resistance locus; 7 showed such linkage. Of these, two were studied in greater detail. The sedimentation profiles of ribosomes from cultures grown at low temperature differed from wild type and from one another. Both mutants lost ribonucleic acid control at low temperature. It is suggested that a high proportion of mutants expressing a cold-sensitive phenotype harbor mutations in genes affecting ribosome synthesis or regulation.

MeSH Terms
Bacterial Proteins/biosynthesis Carbon Isotopes Cold Temperature Drug Resistance, Microbial Genetics, Microbial Mutation RNA, Bacterial/biosynthesis Ribosomes/growth & development Salmonella typhimurium/drug effects Streptomycin/pharmacology Transduction, Genetic Tritium Ultracentrifugation Uracil/metabolism
Chemicals
Bacterial Proteins Carbon Isotopes RNA, Bacterial Tritium Uracil Streptomycin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tai P C
Kessler D P
Ingraham J
References (30)
30 references, click to expand
  1. Three genes that affect Escherichia coli ribosomes.
    J Mol Biol. 1967 Dec 14;30(2):255-75 PMID: 4870510
  2. Regulatory mechanisms and protein synthesis. X. Codon recognition on 30 S ribosomes.
    J Mol Biol. 1966 Oct 28;21(1):145-71 PMID: 5338993
  3. [Thermosensitive mutations of systems activating valine in E. coli].
    Bull Soc Chim Biol (Paris). 1965;47(8):1609-26 PMID: 5321961
  4. Cold-sensitive mutants of Escherichia coli resulting from increased feedback inhibition.
    Proc Natl Acad Sci U S A. 1965 Aug;54(2):451-7 PMID: 5324392
  5. Cold-sensitive mutation of Pseudomonas putida affecting enzyme synthesis at low temperature.
    J Bacteriol. 1967 Dec;94(6):1970-81 PMID: 6074402
  6. Limited capacity for protein synthesis at zero degrees centigrade in Escherichia coli.
    J Mol Biol. 1968 Jan 28;31(2):209-26 PMID: 4865483
  7. Changes in ribosomal proteins associated with mutants in a locus that affects Escherichia coli ribosomes.
    J Mol Biol. 1968 Apr 28;33(2):363-8 PMID: 4882732
  8. The physical properties of the chloromycetin particles.
    J Mol Biol. 1962 May;4:388-94 PMID: 14460745
  9. Revised linkage map of Salmonella typhimurium.
    Bacteriol Rev. 1967 Dec;31(4):354-72 PMID: 4865541
  10. STUDIES ON MICROBIAL RNA.II. TRANSFER OF METHYL GROUPS FROM METHIONINE TO THE RNA OF A RIBONUCLEOPROTEIN PARTICLE.
    J Mol Biol. 1964 Sep;9:638-53 PMID: 14216608
  11. THE CHROMOSOMAL SITE SPECIFYING A RIBOSOMAL PROTEIN IN ESCHERICHIA COLI.
    Proc Natl Acad Sci U S A. 1964 Dec;52:1367-74 PMID: 14243510
  12. Dependency on medium and temperature of cell size and chemical composition during balanced grown of Salmonella typhimurium.
    J Gen Microbiol. 1958 Dec;19(3):592-606 PMID: 13611202
  13. Chemical basis for heterogeneity of ribosomal proteins.
    Proc Natl Acad Sci U S A. 1968 Apr;59(4):1329-36 PMID: 4870863
  14. A genetic locus for the regulation of ribonucleic acid synthesis.
    Proc Natl Acad Sci U S A. 1961 Dec 15;47:2005-14 PMID: 13916843
  15. Nucleic acid metabolism in relation to the lysogenic phenomenon.
    J Bacteriol. 1955 Apr;69(4):460-7 PMID: 14367302
  16. Mutants of Escherichia coli with High Minimal Temperatures of Growth.
    J Bacteriol. 1965 Sep;90(3):611-6 PMID: 16562056
  17. Ribosomal proteins of Escherichia coli. II. Proteins from the 30 s subunit.
    J Mol Biol. 1968 Feb 14;31(3):441-61 PMID: 4866333
  18. Characterization of the RNA formed under conditions of relaxed amino acid control in Escherichia coli.
    Biochim Biophys Acta. 1963 Mar 26;68:380-8 PMID: 13937949
  19. The synthesis and function of ribosomes in a new mutant of Escherichia coli.
    Proc Natl Acad Sci U S A. 1967 Jan;57(1):141-7 PMID: 4860191
  20. Mutations and genetics concerned with the ribosome.
    Cold Spring Harb Symp Quant Biol. 1966;31:623-31 PMID: 4866408
  21. ANALYTICAL ULTRACENTRIFUGATION OF T4R BACTERIOPHAGE DNA IN PREFORMED SUCROSE DENSITY GRADIENTS.
    Biochemistry. 1963 Nov-Dec;2:1206-11 PMID: 14093889
  22. IN VIVO INHIBITION OF RNA METHYLATION IN THE PRESENCE OF CHLORAMPHENICOL.
    J Mol Biol. 1964 Sep;9:831-3 PMID: 14216625
  23. Damage and derepression in Escherichia coli resulting from growth at low temperatures.
    J Bacteriol. 1962 Aug;84:331-9 PMID: 14479392
  24. Streptomycin resistance mutation in Escherichia coli: altered ribosomal protein.
    Science. 1968 Apr 12;160(3824):198-9 PMID: 4868224
  25. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  26. Ribosomal protein differences in a strain of E. coli carrying a suppressor of an ochre mutation.
    Biochem Biophys Res Commun. 1965 Oct 8;21(1):66-71 PMID: 5325233
  27. Altered ribosomes in a suppressor strain of Escherichia coli.
    J Mol Biol. 1966 Apr;16(2):285-301 PMID: 5333511
  28. STREPTOMYCIN ACTION AND THE RIBOSOME.
    Proc Natl Acad Sci U S A. 1964 Apr;51:703-9 PMID: 14166778
  29. STUDIES ON THE RIBOSOMES OF STREPTOMYCIN-SENSITIVE AND RESISTANT STRAINS OF ESCHERICHIA COLI.
    Proc Natl Acad Sci U S A. 1964 Apr;51:659-64 PMID: 14166773
  30. A mutation suppressing streptomycin dependence. I. An effect on ribosome function.
    J Mol Biol. 1967 Apr 14;25(1):99-109 PMID: 5340532
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.97.3.1298-1304.1969
Published
1969-03-00
Pages
1298-304
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC249847
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.97.3.1298-1304.1969 PMC Full Text View journal details
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