Recessive lethals: a new class of nonsense suppressors in Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 63 ·No. 2 ·1969-06-00 ·Pages 392-9

Soll L, Berg P

Abstract

Two new nonsense suppressors in Escherichia coli were found in partial diploids carrying F'14 and were shown to be on the episome. These suppressors can exist only in cells which also contain the su(-) allele, i.e., su(+)/su(-) heterozygotes. Presumably the mutations cause an alteration of an essential cellular component, the complete loss of which is lethal. Su7, an amber suppressor, has an efficiency of 76 per cent and su8, an ochre suppressor, an efficiency of 4 per cent.

MeSH Terms

Alleles Bacteriophage Typing Escherichia coli Genes, Lethal Genes, Recessive Heterozygote Mutation Suppression, Genetic

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Soll L

Berg P

References (20)

20 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.63.2.392

Published

1969-06-00

Pages

392-9

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC223577

Subset

External Links

PubMed source DOI: 10.1073/pnas.63.2.392 PMC Full Text View journal details

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Recessive lethals: a new class of nonsense suppressors in Escherichia coli.

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