Inhibition by pactamycin of the initiation of protein synthesis. Binding of N-acetylphenylalanyl transfer ribonucleic acid and polyuridylic acid to ribosomes.

Amines Anti-Bacterial Agents/pharmacology Bacterial Proteins/biosynthesis Carbon Isotopes Centrifugation, Zonal Chlortetracycline/pharmacology Depression, Chemical Escherichia coli/metabolism Guanine Nucleotides Magnesium/pharmacology Phenylalanine/metabolism Polynucleotides/metabolism Puromycin/pharmacology Quaternary Ammonium Compounds/pharmacology RNA, Bacterial/metabolism RNA, Transfer/metabolism Ribosomes/metabolism Streptomycin/pharmacology Time Factors Tritium Uracil Nucleotides/metabolism

Amines Anti-Bacterial Agents Bacterial Proteins Carbon Isotopes Guanine Nucleotides Polynucleotides Quaternary Ammonium Compounds RNA, Bacterial Uracil Nucleotides Tritium Phenylalanine Puromycin RNA, Transfer Magnesium Chlortetracycline Streptomycin