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PMID: 49059 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 6 ·1975-06-00 ·Pages 2357-60

Janeway CA, Sakato N, Eisen HN

Abstract

The ability of thymus-derived lymphocytes (T cells) from BALB/c mice to recognize the individually specific antigenic determinants (idiotypes) of BALB/c myeloma proteins was tested. Spleen cells from donor mice immunized with a given myeloma protein greatly augmented the response of hapten-specific bone marrow-derived, thymus-independent lymphocytes (cells) to a hapten conjugate of the immunizing myeloma protein. This helper effect was specific for the myeloma protein idiotype; responses to hapten conjugates of similar myeloma proteins, bearing different idiotypic determinants, were not augmented by these spleen cells. That the helper cell is a T cell was shown by its marked sensitivity to cytolysis with an isoantiserum specific for T cells (anti-Thy-1-2) and complement. The discrimination between idiotypes by such T cells is roughly comparable to that of the antibody produced by the donors of the helper cells.

MeSH Terms
Animals B-Lymphocytes/immunology Complement System Proteins Cytotoxicity Tests, Immunologic Epitopes Haptens Hemocyanins Immunization Mice/immunology Mice, Inbred BALB C Myeloma Proteins/immunology Nitrobenzenes Ovalbumin Rabbits/immunology Spleen/cytology,immunology T-Lymphocytes/immunology
Chemicals
Epitopes Haptens Myeloma Proteins Nitrobenzenes Ovalbumin Complement System Proteins Hemocyanins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Janeway C A
Sakato N
Eisen H N
References (21)
21 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.72.6.2357
Published
1975-06-00
Pages
2357-60
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC432757
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.72.6.2357 PMC Full Text View journal details
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