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PMID: 49080 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Tetanus toxin: direct evidence for retrograde intraaxonal transport.

Science (New York, N.Y.) ·Vol. 188 ·No. 4191 ·1975-05-30 ·Pages 945-7

Price DL, Griffin J, Young A, Peck K, Stocks A

Abstract

The neurotoxin tetanospasmin causes tetanus when it reaches the central nervous system. In this autoradiographic study, 125-I-labeled tetanospasmin was injected into the leg muscles of rodents, and the nerves supplying these muscles were crushed. The labeled toxin accumulated within axons on the distal side of the crush. This study provides direct evidence for retrograde axonal transport of a macromolecular toxin that acts at synapses in the central nervous system.

MeSH Terms

Animals Autoradiography Axonal Transport Axons/metabolism Hindlimb/innervation Injections, Intramuscular Iodine Radioisotopes Mice Models, Biological Muscles/innervation Nerve Crush Neural Inhibition/drug effects Neuromuscular Junction/metabolism Rats Sciatic Nerve/metabolism Synapses/drug effects Synaptic Transmission Tetanus Toxin/administration & dosage,metabolism,pharmacology

Chemicals

Iodine Radioisotopes Tetanus Toxin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Price D L

Griffin J

Young A

Peck K

Stocks A

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.49080

Published

1975-05-30

Pages

945-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.49080 View journal details

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