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PMID: 4913783 Published · ppublish English Journal Article

Autoimmunization with irradiated tumour cells in human malignant melanoma.

British medical journal ·Vol. 2 ·No. 5712 ·1970-06-27 ·Pages 752-4

Ikonopisov RL, Lewis MG, Hunter-Craig ID, Bodenham DC, Phillips TM, Cooling CI, Proctor J, Fairley GH, Alexander P

Abstract

Thirteen patients have been immunized with their own irradiated melanoma cells on one or more occasions. Following these autografts tumour-specific cytotoxic antibodies were produced, the longest response lasting 14 days. This procedure had no apparent effect on the course of the disease in these patients.

MeSH Terms
Adult Aged Antibody Formation Autoantibodies/analysis Complement Fixation Tests Female Fluorescent Antibody Technique Humans Immunization Male Melanoma/immunology,therapy Middle Aged Neoplasm Transplantation RNA, Neoplasm/biosynthesis Radiation Effects Transplantation, Autologous
Chemicals
Autoantibodies RNA, Neoplasm
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Ikonopisov R L
Lewis M G
Hunter-Craig I D
Bodenham D C
Phillips T M
Cooling C I
Proctor J
Fairley G H
Alexander P
Article Info
Journal
British medical journal
Abbr.
Br Med J
ISSN
0007-1447
Published
1970-06-27
Pages
752-4
Language
English
Region
England
NLM ID
0372673
PMCID
PMC1700876
Subset
IM
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