A haematological study of patients receiving long-term treatment with trimethoprim and sulphonamide.

Journal of clinical pathology ·Vol. 23 ·No. 5 ·1970-07-00 ·Pages 392-6

Jenkins GC, Hughes DT, Hall PC

Abstract

The haematological effects of long-term treatment for three months with a combination of trimethoprim and sulphamethoxazole were studied in 10 cases of chronic bronchitis. Trimethoprim selectively inhibits dihydrofolate reductase in bacteria but not in man. Only minor effects on folate metabolism were observed in nine cases, causing no clinical concern. Some degree of thrombocytopenia occurred in the tenth case which improved when folinic acid was given.

MeSH Terms

Aged Blood Cell Count Blood Platelets Bronchitis/drug therapy Clinical Trials as Topic Erythrocyte Count Female Folic Acid/blood Folic Acid Antagonists/adverse effects Hemoglobinometry Humans Leukocyte Count Male Middle Aged Neutrophils Pyrimidines/adverse effects Sulfamethoxazole/adverse effects,therapeutic use Thrombocytopenia/chemically induced

Chemicals

Folic Acid Antagonists Pyrimidines Folic Acid Sulfamethoxazole

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Jenkins G C

Hughes D T

Hall P C

References (10)

10 references, click to expand

Trimethoprim: laboratory and clinical studies.
J Clin Pathol. 1968 Mar;21(2):202-9 PMID: 5697054
5-BENZYL-2,4-DIAMINOPYRIMIDINES AS ANTIBACTERIAL AGENTS. I. SYNTHESIS AND ANTIBACTERIAL ACTIVITY IN VITRO.
J Med Pharm Chem. 1962 Nov;91:1103-23 PMID: 14056446
Experimental nutritional folate deficiency in man.
Trans Assoc Am Physicians. 1962;75:307-20 PMID: 13953904
MICROBIOLOGICAL ASSAY OF FOLIC ACID ACTIVITY IN HUMAN SERUM.
J Clin Pathol. 1964 Nov;17:660-5 PMID: 14227437
THE "INDUCTION" OF DIHYDROFOLIC REDUCTASE ACTIVITY IN LEUKOCYTES AND ERYTHROCYTES OF PATIENTS TREATED WITH AMETHOPTERIN.
J Clin Invest. 1963 Apr;42(4):466-75 PMID: 16695899
Effects of trimethoprim on folate metabolism in man.
Clin Pharmacol Ther. 1968 Sep-Oct;9(5):550-60 PMID: 5302846
A spectrophotometric method for estimating formimino-glutamic and urocanic acid.
Br Med J. 1962 Jan 6;1(5270):27-9 PMID: 13878012
FOLIC ACID.
Annu Rev Med. 1965;16:359-70 PMID: 14276573
Mechanism of pyrimethamine-induced megaloblastosis in human bone marrow.
N Engl J Med. 1969 Jun 12;280(24):1316-9 PMID: 5771778
Method of assay of red cell folate activity and the value of the assay as a test for folate deficiency.
J Clin Pathol. 1966 Jan;19(1):17-28 PMID: 5904976

Article Info

Journal

Journal of clinical pathology

Abbr.

J Clin Pathol

ISSN

0021-9746

DOI

10.1136/jcp.23.5.392

Published

1970-07-00

Pages

392-6

Language

English

Region

England

NLM ID

0376601

PMCID

PMC476778

Subset

External Links

PubMed source DOI: 10.1136/jcp.23.5.392 PMC Full Text View journal details

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A haematological study of patients receiving long-term treatment with trimethoprim and sulphonamide.

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