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PMID: 4922754 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial

Folic acid in folate-deficient patients with epilepsy.

British medical journal ·Vol. 4 ·No. 5736 ·1970-12-12 ·Pages 644-8

Grant RH, Stores OP

Abstract

A double-blind trial using folic acid 15 mg. daily and identical placebo was carried out in 51 epileptic patients having a serum folate level below 3.6 ng./ml. Treatment was for a minimum of six months and in 41 patients was for more than one year. There were no significant changes in the frequency of seizures, behaviour, and personality, or in a number of cognitive functions.

MeSH Terms

Adolescent Adult Behavior Clinical Trials as Topic Epilepsy/complications,drug therapy Female Folic Acid/blood,therapeutic use Folic Acid Deficiency/complications,drug therapy Humans Intelligence Tests Male Memory Middle Aged Personality Inventory Placebos

Chemicals

Placebos Folic Acid

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Grant R H

Stores O P

References (17)

17 references, click to expand

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Effects of folic acid on the mental state and fit-frequency of drug-treated epileptic patients.
Lancet. 1967 May 20;1(7499):1086-8 PMID: 4164775
Folic acid and neuropathy in epilepsy.
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The measurement of memory in clinical practice.
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Mechanism of folate deficiency in patients receiving phenytoin.
Lancet. 1968 Sep 7;2(7567):528-30 PMID: 4175395
Impairment of intestinal deconjugation of dietary folate. A possible explanation of megaloblastic anaemia associated with phenytoin therapy.
Lancet. 1968 Sep 7;2(7567):530-2 PMID: 4175396
Folic acid deficiency from anticonvulsant therapy.
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Mental effects of anticonvulsants, and folic acid metabolism.
Brain. 1968 Jun;91(2):197-214 PMID: 5721926
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Epilepsy and folate deficiency.
Br Med J. 1969 Dec 27;4(5686):807-8 PMID: 5359954
Toxicity of folic acid given in pharmacological doses to healthy volunteers.
Lancet. 1970 Jan 10;1(7637):61-3 PMID: 4188624
Effects of folic acid on fit-frequency and behaviour in epileptics on anticonvulsants.
Lancet. 1970 Apr 25;1(7652):867-8 PMID: 4191511
Iatrogenic disorders in epilepsy.
Mod Trends Neurol. 1970;5(0):271-86 PMID: 4368783
Megaloblastic anaemia due to phenobarbitone; the convulsant action of therapeutic doses of folic acid.
Br Med J. 1960 Apr 9;1(5179):1099-102 PMID: 13809099
Observation of children in a psychiatric inpatient unit. Design of behavioural rating scale for nursing staff.
Br J Psychiatry. 1963 Jul;109:572-8 PMID: 13986252
SUBNORMAL SERUM FOLATE AND MACROCYTOSIS ASSOCIATED WITH ANTICONVULSANT DRUG THERAPY.
Blood. 1964 Jan;23:68-86 PMID: 14107052
SERUM PHENYTOIN DETERMINATIONS IN EPILEPTICS.
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Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.4.5736.644

Published

1970-12-12

Pages

644-8

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1820248

Subset

External Links

PubMed source DOI: 10.1136/bmj.4.5736.644 PMC Full Text

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Folic acid in folate-deficient patients with epilepsy.

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