Subacute sclerosing panencephalitis: isolation of suppressed measles virus from lymph node biopsies.

Science (New York, N.Y.) ·Vol. 173 ·No. 3999 ·1971-08-27 ·Pages 840-1

Horta-Barbosa L, Hamilton R, Wittig B, Fuccillo DA, Sever JL, Vernon ML

Abstract

Measles virus was isolated in mixed cultures of lymph node cells and HeLa cells. The agent was isolated by cocultivation from biopsy specimens of two of five patients with subacute sclerosing panencephalitis. The virus was identified by hemagglutination-inhibition, immunofluorescent, and neutralization tests. Biopsies from controls did not show evidence of measles virus.

MeSH Terms

Adolescent Biopsy Child Female Fluorescent Antibody Technique HeLa Cells Hemagglutination Inhibition Tests Humans Lymph Nodes/microbiology Male Measles virus/isolation & purification Neutralization Tests Subacute Sclerosing Panencephalitis/microbiology Virus Cultivation

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Horta-Barbosa L

Hamilton R

Wittig B

Fuccillo D A

Sever J L

Vernon M L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.173.3999.840

Published

1971-08-27

Pages

840-1

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.173.3999.840 View journal details

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Subacute sclerosing panencephalitis: isolation of suppressed measles virus from lymph node biopsies.

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