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PMID: 493995 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Noncycling tumor cells are sensitive targets for the antiproliferative activity of human interferon.

Science (New York, N.Y.) ·Vol. 206 ·No. 4422 ·1979-11-30 ·Pages 1091-3

Horoszewicz JS, Leong SS, Carter WA

Abstract

Resting Burkitt's lymphoma cells (Daudi) in culture are more sensitive targets for the antiproliferative activity of purified human fibroblast interferon than cells that are rapidly multiplying. Thus, interferon may be of significant clinical value in neoplasms involving stem cells and, after chemotherapy, in suppressing the reemergence of tumors.

MeSH Terms
Burkitt Lymphoma/drug therapy,pathology Cell Cycle/drug effects Cell Division/drug effects Cell Line Cells, Cultured Humans Interferons/pharmacology,therapeutic use Lymphocytes/drug effects
Chemicals
Interferons
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Horoszewicz J S
Leong S S
Carter W A
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.493995
Published
1979-11-30
Pages
1091-3
Language
English
Region
United States
NLM ID
0404511
Subset
IM
External Links
PubMed source DOI: 10.1126/science.493995 View journal details
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