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PMID: 4940869 Published · ppublish English Journal Article

Characterization of an unusual strain of proteus rettgeri associated with an outbreak of nosocomial urinary-tract infection.

Applied microbiology ·Vol. 22 ·No. 3 ·1971-09-00 ·Pages 278-83

Traub WH, Craddock ME, Raymond EA, Fox M, McCall CE

Abstract

An outbreak of nosocomial urinary-tract infection was caused by a strain of Proteus rettgeri that fermented lactose overnight and was resistant to all antimicrobial drugs tested. The nonmotile isolates shared an O (somatic) antigen that differed from those of wild-type P. rettgeri. The organisms proved markedly serum-sensitive. In rats, the isolates elicited an acute interstitial nephritis with associated transient bacteriuria. Attempts to transfer the lac(+) trait and drug-resistance markers to recipient strains of Escherichia coli K-12 failed; exposure of the isolates to acridine orange yielded small numbers of non-lactose-fermenting variants which, however, were still as drug-resistant as before. Epidemiological studies failed to uncover the source of this unique strain and appeared to indicate exogenous spread of infection.

MeSH Terms
Acridines Agglutination Tests Animals Anti-Bacterial Agents/pharmacology Antigens, Viral/analysis Bacteriological Techniques Bacteriuria/microbiology Blood Bactericidal Activity Conjugation, Genetic Cross Infection/etiology,microbiology Disease Outbreaks/microbiology Disease Reservoirs Drug Resistance, Microbial Female Fermentation Genetic Variation Genetics, Microbial Hemagglutination Tests Humans Immune Sera Lactose/metabolism Microbial Sensitivity Tests Mutagens Proteus/drug effects,immunology,isolation & purification,metabolism,pathogenicity Proteus Infections/etiology,microbiology Rabbits Rats Urinary Tract Infections/etiology,microbiology
Chemicals
Acridines Anti-Bacterial Agents Antigens, Viral Immune Sera Mutagens Lactose
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Traub W H
Craddock M E
Raymond E A
Fox M
McCall C E
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30 references, click to expand
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Article Info
Journal
Applied microbiology
Abbr.
Appl Microbiol
ISSN
0003-6919
DOI
10.1128/am.22.3.278-283.1971
Published
1971-09-00
Pages
278-83
Language
English
Region
United States
NLM ID
7605802
PMCID
PMC376299
Subset
IM
External Links
PubMed source DOI: 10.1128/am.22.3.278-283.1971 PMC Full Text
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