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PMID: 4942773 Published · ppublish English Journal Article

Evidence that the majority of leucine transfer ribonucleic acid is not involved in repression in Salmonella typhimurium.

Journal of bacteriology ·Vol. 108 ·No. 2 ·1971-11-00 ·Pages 951-3

Freundlich M, Trela J, Peng W

Abstract

Leucine transfer ribonucleic acid (tRNA) was almost fully charged, and the isoleucine-valine and leucine enzymes remained derepressed when trifluoroleucine was added to a leucine auxotroph. High levels of charged leucine tRNA and derepression were also found in a leucyl-tRNA synthetase mutant.

MeSH Terms
Amino Acyl-tRNA Synthetases/metabolism Culture Media Enzyme Repression/drug effects Fluorine/pharmacology Genetics, Microbial Hydro-Lyases/metabolism Isoleucine/metabolism Leucine/metabolism,pharmacology Lyases/metabolism Mutation Pyruvates RNA, Bacterial/isolation & purification RNA, Transfer/metabolism Salmonella typhimurium/enzymology,growth & development,metabolism Threonine Transfer RNA Aminoacylation Valine/metabolism
Chemicals
Culture Media Pyruvates RNA, Bacterial Isoleucine Fluorine Threonine RNA, Transfer Lyases Hydro-Lyases Amino Acyl-tRNA Synthetases Leucine Valine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Freundlich M
Trela J
Peng W
References (8)
8 references, click to expand
  1. Histidine regulatory mutants in Salmonella typhimurium 3. A class of regulatory mutants deficient in tRNA for histidine.
    J Mol Biol. 1966 Dec 28;22(2):335-47 PMID: 5339689
  2. Mutants of Escherichia coli requiring methionine or vitamin B12.
    J Bacteriol. 1950 Jul;60(1):17-28 PMID: 15436457
  3. Control of isoleucine, valine, and leucine biosynthesis. VI. Effect of 5',5',5'-trifluoroleucine on repression in Salmonella typhimurium.
    J Bacteriol. 1969 Jul;99(1):101-6 PMID: 4895839
  4. Characterization of altered forms of glycyl transfer ribonucleic acid synthetase and the effects of such alterations on aminoacyl transfer ribonucleic acid synthesis in vivo.
    J Bacteriol. 1970 Apr;102(1):204-12 PMID: 4908672
  5. Control of isoleucine, valine, and leucine biosynthesis. I. Multivalent repression.
    Proc Natl Acad Sci U S A. 1962 Oct 15;48:1804-8 PMID: 13959618
  6. Mutants of Salmonella typhimurium with an altered leucyl-transfer ribonucleic acid synthetase.
    J Bacteriol. 1971 Apr;106(1):213-20 PMID: 4928008
  7. Roles of amino acid activating enzymes in cellular physiology.
    Bacteriol Rev. 1966 Dec;30(4):701-19 PMID: 5342516
  8. Valyl-Transfer RNA: Role in Repression of the Isoleucine-Valine Enzymes in Escherichia coli.
    Science. 1967 Aug 18;157(3790):823-5 PMID: 17842790
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.108.2.951-953.1971
Published
1971-11-00
Pages
951-3
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC247167
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.108.2.951-953.1971 PMC Full Text View journal details
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