Enhancement of the phenylalanyl-oligonucleotide binding to the peptidyl recognition center of ribosomal peptidyltransferase and inhibition of the chloramphenicol binding to ribosomes.

Acyltransferases/metabolism Adenine Nucleotides/metabolism,pharmacology Anti-Bacterial Agents/pharmacology Binding Sites Carbon Isotopes Chloramphenicol/metabolism Cytosine Nucleotides/metabolism,pharmacology Escherichia coli/cytology,drug effects,enzymology,metabolism Ethanol/pharmacology Kinetics Peptide Chain Elongation, Translational Peptides Phenylalanine/metabolism,pharmacology Polynucleotides/metabolism,pharmacology Puromycin/metabolism Ribosomes/drug effects,enzymology,metabolism Tritium

Adenine Nucleotides Anti-Bacterial Agents Carbon Isotopes Cytosine Nucleotides Peptides Polynucleotides Tritium Ethanol Phenylalanine Puromycin Chloramphenicol Acyltransferases