Relation of renal growth to diabetic glomerulosclerosis.

Lancet (London, England) ·Vol. 1 ·No. 7916 ·1975-05-17 ·Pages 1120-1

Levin NW, Silveira E, Cortes P, Rubenstein AH

Abstract

In diabetes mellitus abnormal quantiites of glycoprotein may be formed in the basement membrane of the glomerulus and both renal function and size may increase. It is suggested that these changes, of quite different potential significance, have a common origin an increased rate of uridine-triphosphate synthesis resulting from hyperglycemia.

MeSH Terms

Animals Basement Membrane Diabetes Complications Diabetes Mellitus/metabolism Diabetes Mellitus, Experimental/metabolism Diabetic Nephropathies/etiology,metabolism Glycogen/biosynthesis Glycoproteins/biosynthesis,metabolism Humans Hyperglycemia/complications,metabolism Hypertrophy/etiology Kidney/metabolism Kidney Diseases/etiology Kidney Glomerulus/metabolism RNA/biosynthesis Rats Sclerosis/etiology Uracil Nucleotides/biosynthesis

Chemicals

Glycoproteins Uracil Nucleotides RNA Glycogen

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Levin N W

Silveira E

Cortes P

Rubenstein A H

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(75)92505-2

Published

1975-05-17

Pages

1120-1

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(75)92505-2 View journal details

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Relation of renal growth to diabetic glomerulosclerosis.

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