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PMID: 4969551 Published · ppublish English Clinical Trial Comparative Study Journal Article Randomized Controlled Trial

Clinical evaluation of verapamil in angina pectoris.

British medical journal ·Vol. 3 ·No. 5612 ·1968-07-27 ·Pages 224-7

Sandler G, Clayton GA, Thornicroft SG

Abstract

A controlled double-blind study of verapamil in 16 anginal patients used two dose levels-40 mg. t.d.s. and 120 mg. t.d.s.-and was compared with propranolol 100 mg. t.d.s. At the higher dosage verapamil produced a significant improvement in frequency of angina, trinitrin consumption, and exercise tolerance, and had a favourable and significant effect on the amount and duration of ischaemic S-T depression occurring in the electrocardiogram during exercise. In the lower dose verapamil produced significant subjective improvement but no objective benefit in the electrocardiogram. No significant differences were found between the favourable results with the higher dosage of verapamil and propranolol.The action of verapamil is not fully understood, but its favourable effects in angina may be due to a direct action on the myocardium, possibly with accompanying coronary vasodilatation.

MeSH Terms
Adult Aged Angina Pectoris/drug therapy Anti-Arrhythmia Agents/therapeutic use Blood Pressure/drug effects Clinical Trials as Topic Electrocardiography Exercise Test Female Humans Male Middle Aged Nitriles/therapeutic use Nitroglycerin/therapeutic use Propranolol/therapeutic use Vasodilator Agents/therapeutic use Verapamil
Chemicals
Anti-Arrhythmia Agents Nitriles Vasodilator Agents Propranolol Verapamil Nitroglycerin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sandler G
Clayton G A
Thornicroft S G
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30 references, click to expand
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Article Info
Journal
British medical journal
Abbr.
Br Med J
ISSN
0007-1447
DOI
10.1136/bmj.3.5612.224
Published
1968-07-27
Pages
224-7
Language
English
Region
England
NLM ID
0372673
PMCID
PMC1986217
Subset
IM
External Links
PubMed source DOI: 10.1136/bmj.3.5612.224 PMC Full Text
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