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PMID: 4977166 Published · ppublish English Journal Article

Ribonucleic acid synthesis in chick embryo cells infected with fowl-plague virus.

Journal of virology ·Vol. 3 ·No. 4 ·1969-04-00 ·Pages 429-38

Skehel JJ, Burke DC

Abstract

Increases in ribonucleic acid (RNA) polymerase activity were detected in both the nuclear and ribosomal fractions of chick embryo cells infected with fowl-plague virus. These were observed only in the presence of all four nucleoside triphosphates and were not affected by actinomycin D. The RNA polymerase activity of the ribosomal fraction was shown to be associated with a component of infected cells of sedimentation coefficient approximately 70S. This component also contained infected cell-specific RNA and protein molecules.

MeSH Terms
Animals Carbon Isotopes Cell Nucleus Centrifugation, Density Gradient Chick Embryo Culture Techniques Dactinomycin/pharmacology Edetic Acid/pharmacology Electrophoresis, Disc Hydrogen-Ion Concentration Influenza A virus/isolation & purification,metabolism Magnesium/pharmacology Manganese/pharmacology Nucleotides/metabolism RNA Nucleotidyltransferases/metabolism RNA, Viral/biosynthesis Ribosomes Tritium Uracil Nucleotides/metabolism Uridine/metabolism Valine/metabolism
Chemicals
Carbon Isotopes Nucleotides RNA, Viral Uracil Nucleotides Tritium Dactinomycin Manganese Edetic Acid RNA Nucleotidyltransferases Valine Magnesium Uridine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Skehel J J
Burke D C
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23 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.3.4.429-438.1969
Published
1969-04-00
Pages
429-38
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC375788
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.3.4.429-438.1969 PMC Full Text View journal details
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