Aging of alpha-crystallins during development of the lens.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 64 ·No. 1 ·1969-09-00 ·Pages 404-10

Palmer WG, Papaconstantinou J

Abstract

Fetal alpha-crystallin from the bovine lens can be resolved into three major subunit fractions by ion exchange chromatography. A fourth subunit gradually arises during the development of the lens. Incorporation studies indicate that this subunit is not formed by de novo synthesis but by the chemical conversion of one subunit into another. Possible mechanisms for this conversion are discussed.

MeSH Terms

Aging Amino Acids/analysis Animals Carbon Isotopes Cattle Chromatography, Ion Exchange Crystallins/analysis Immunodiffusion Lens, Crystalline/embryology

Chemicals

Amino Acids Carbon Isotopes Crystallins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Palmer W G

Papaconstantinou J

References (9)

9 references, click to expand

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Biochim Biophys Acta. 1966 May 26;121(1):69-78 PMID: 5956951
Hemoglobin synthesis during amphibian metamorphosis. I. Chemical studies on the hemoglobins from the larval and adult stages of Rana catesbeiana.
J Mol Biol. 1968 Mar 28;32(3):481-92 PMID: 5644917
Increase in the complexity of alpha-crystallins during differentiation of lens cells.
Nature. 1968 Jul 13;219(5150):170-2 PMID: 4968987
The primary structure of Golfingia gouldii hemerythrin. Oder of peptides in fragments produced by tryptic digestion of succinylated hemerythrin. Complete amino acid sequence.
Biochemistry. 1968 Nov;7(11):3868-78 PMID: 5722254
Biochemistry of bovine lens proteins. 3. Chemical and physical properties of alpha-crystallin subunits.
Biochemistry. 1968 Jan;7(1):243-53 PMID: 4991478
Splitting and recombination of alpha-crystallin.
Exp Eye Res. 1962 Jun;1:300-5 PMID: 13971729
The ontogeny of chick embryo hemoglobin.
Proc Natl Acad Sci U S A. 1962 Sep 15;48:1582-90 PMID: 14007439
The preparation and enzymatic hydrolysis of reduced and S-carboxymethylated proteins.
J Biol Chem. 1963 Feb;238:622-7 PMID: 14023808
DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.
Ann N Y Acad Sci. 1964 Dec 28;121:404-27 PMID: 14240539

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.64.1.404

Published

1969-09-00

Pages

404-10

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC286176

Subset

External Links

PubMed source DOI: 10.1073/pnas.64.1.404 PMC Full Text View journal details

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Aging of alpha-crystallins during development of the lens.

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