Hamster-tropic sarcomagenic and nonsarcomagenic viruses derived from hamster tumors induced by the Gross pseudotype of Moloney sarcoma virus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 65 ·No. 2 ·1970-02-00 ·Pages 310-7

Kelloff G, Huebner RJ, Lee YK, Toni R, Gilden R

Abstract

Hamster sarcomas induced by the Gross pseudotype of Moloney sarcoma virus yielded a virus sarcomagenic for hamsters but not mice. This virus was able to produce foci on hamster embryo cells, but not on mouse embryo cells. A hamster-tropic nonfocus-forming helper virus was also found in the viral stocks. These hamster-tropic viruses are not immunologically related to the murine viruses in the original inoculum but appear to represent indigenous C-type RNA viruses of the hamster.

MeSH Terms

AKR murine leukemia virus/immunology,pathogenicity Animals Cell Transformation, Neoplastic Complement Fixation Tests Cricetinae Culture Techniques Embryo, Mammalian/cytology Fibroblasts/microbiology Helper Viruses/pathogenicity Immunodiffusion Kidney Neoplasms/microbiology Liver Neoplasms/microbiology Lymphoma/microbiology Mice Microscopy, Electron Moloney murine leukemia virus/immunology,pathogenicity Neutralization Tests Sarcoma, Experimental Splenic Neoplasms/microbiology Tritium Uridine/metabolism

Chemicals

Tritium Uridine

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Kelloff G

Huebner R J

Lee Y K

Toni R

Gilden R

References (17)

17 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.65.2.310

Published

1970-02-00

Pages

310-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC282903

Subset

External Links

PubMed source DOI: 10.1073/pnas.65.2.310 PMC Full Text View journal details

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Hamster-tropic sarcomagenic and nonsarcomagenic viruses derived from hamster tumors induced by the Gross pseudotype of Moloney sarcoma virus.

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